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Literature summary extracted from
- Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase (1975), J. Biol. Chem., 250, 4549-4555.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.189 | angiotensin I | at 0.1 mM concentration | Gallus gallus |  |
| 1.1.1.189 | ATP | at 1mM concentration slight stimulation | Gallus gallus | |
| 1.1.1.189 | CTP | at 1mM concentration slight stimulation | Gallus gallus | |
| 1.1.1.189 | GTP | at 1mM concentration slight stimulation | Gallus gallus | |
| 1.1.1.189 | Sodium diphosphate | - |
Gallus gallus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.189 | 5,5'-dithiobis(2-nitrobenzoate) | complete inhibition at 1 mM concentration | Gallus gallus | |
| 1.1.1.189 | p-chloromercuribenzoate | complete inhibition at 1 mM concentration | Gallus gallus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.189 | 45000 | 55000 | gel filtration | Gallus gallus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.189 | Gallus gallus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.189 | - |
Gallus gallus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.189 | heart | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.189 | 5.73 | - |
- |
Gallus gallus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.189 | (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ | - |
Gallus gallus | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.189 | 7.4 | - |
assay at | Gallus gallus |
| 1.1.1.189 | 7.4 | 8.8 | - |
Gallus gallus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.189 | NADPH | - |
Gallus gallus | |
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Release 2023.1 (January 2023)
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