Literature summary extracted from

Kaplan, L.; Lee, S.C.; Levine, L.
Partial purification and some properties of human erythrocyte prostaglandin 9-ketoreductase and 15-hydroxyprostaglandin dehydrogenase (1975), Arch. Biochem. Biophys., 167, 287-293.

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.1.1.189	0.09	-	prostaglandin E2	-	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.1.1.189	cytosol	-	Homo sapiens	5829	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.189	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.189	partial purification	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.189	erythrocyte	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.1.1.189	0.00036	-	-	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.189	(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NAD(P)+	catalyzed by a 15-hydroxyprostaglandin dehydrogenase	Homo sapiens	(5Z,13E)-11alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H	-	?
1.1.1.189	(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+	-	Homo sapiens	(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+	-	r
1.1.1.189	(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+	catalyzed by a 15-hydroxyprostaglandin dehydrogenase	Homo sapiens	(5Z,13E)-9alpha,11alpha-dihydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+	-	?
1.1.1.189	(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+	catalyzed by a 15-hydroxyprostaglandin dehydrogenase	Homo sapiens	(5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH	-	?

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
1.1.1.189	37	-	-	Homo sapiens

Temperature Stability [°C]

EC Number	Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
1.1.1.189	45	-	25% activity after incubation at 45°C for 10 min	Homo sapiens

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
1.1.1.189	7.4	-	assay at	Homo sapiens
1.1.1.189	7.4	9	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.189	NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)