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Literature summary extracted from

  • Schieber, A.; Ghisla, S.
    Prostaglandin 9-ketoreductase from pig and human kidney: purification, properties and identity with human carbonyl reductase (1992), Eicosanoids, 5, S37-38.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.189 Zn2+ 1.9 g-atoms per mol enzyme Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.189 32000
-
gel filtration, 4 isoforms Sus scrofa
1.1.1.189 34000
-
gel filtration, 4 isoforms Homo sapiens
1.1.1.189 35000
-
alpha, 1 * 35000, SDS-PAGE Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.189 Homo sapiens
-
-
-
1.1.1.189 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.189
-
Homo sapiens
1.1.1.189
-
Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.189 kidney
-
Homo sapiens
-
1.1.1.189 kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.189 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NAD(P)+
-
Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
-
?
1.1.1.189 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NAD(P)+
-
Sus scrofa (5Z,13E)-11alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
-
ir
1.1.1.189 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
r
1.1.1.189 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ enzyme is pro(S) stereo selective with regard to hydrogen transfer from NADPH Sus scrofa (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
r
1.1.1.189 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Homo sapiens (5Z,13E)-9alpha,11alpha-dihydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
-
?
1.1.1.189 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Sus scrofa (5Z,13E)-9alpha,11alpha-dihydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
-
ir
1.1.1.189 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+
-
Homo sapiens (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH
-
?
1.1.1.189 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+
-
Sus scrofa (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH
-
ir

Subunits

EC Number Subunits Comment Organism
1.1.1.189 monomer alpha, 1 * 34000, SDS-PAGE Homo sapiens
1.1.1.189 monomer alpha, 1 * 35000, SDS-PAGE Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.189 NAD+ preferential 15-keto prostaglandin F2alpha formation Sus scrofa
1.1.1.189 NADPH
-
Homo sapiens
1.1.1.189 NADPH
-
Sus scrofa