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Literature summary extracted from

  • Suzuki, T.; Fujii, Y.; Miyano, M.; Chen, L.Y.; Takahashi, T.; Watanabe, K.
    cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase (1999), J. Biol. Chem., 274, 241-248.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.188 expression in COS-7 cells Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.188 H170C fully active Bos taurus
1.1.1.188 K225S 2fold as active as wild-type Bos taurus
1.1.1.188 N306Y half as active as wild-type Bos taurus
1.1.1.188 R223L 5fold as active as wild-type Bos taurus
1.1.1.188 R27E fully active Bos taurus
1.1.1.188 R91Q fully active Bos taurus
1.1.1.188 S301R 2.5fold as active as wild-type Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.188 0.0007
-
9,10-phenanthrenequinone native lung prostaglandin F synthase Bos taurus
1.1.1.188 0.0011
-
9,10-phenanthrenequinone expressed liver prostaglandin F synthase Bos taurus
1.1.1.188 0.002
-
9,10-phenanthrenequinone native liver prostaglandin F synthase Bos taurus
1.1.1.188 0.01
-
prostaglandin H2 native lung prostaglandin F synthase Bos taurus
1.1.1.188 0.01
-
Prostaglandin D2 native liver prostaglandin F synthase Bos taurus
1.1.1.188 0.015
-
Prostaglandin D2 expressed liver prostaglandin F synthase Bos taurus
1.1.1.188 0.025
-
prostaglandin H2 native and expressed liver prostaglandin F synthase Bos taurus
1.1.1.188 0.12
-
Prostaglandin D2 native lung prostaglandin F synthase Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.188 36740
-
amino acid analysis, SDS-PAGE Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.188 Bos taurus
-
two isozymes, lung-type and liver-type
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.188
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.188 liver
-
Bos taurus
-
1.1.1.188 lung
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
-
Bos taurus (5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+
-
?
1.1.1.188 9,10-phenanthrenequinone + NADPH
-
Bos taurus ?
-
?
1.1.1.188 prostaglandin H2 + NADPH + H+
-
Bos taurus (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.188 NADPH
-
Bos taurus