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Literature summary extracted from

  • Suzuki-Yamamoto, T.; Nishizawa, M.; Fukui, M.; Okuda-Ashitaka, E.; Nakajima, T.; Ito, S.; Watanabe, K.
    cDNA cloning, expression and characterization of human prostaglandin F synthase (1999), FEBS Lett., 462, 335-340.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.188 expression in Escherichia coli Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.188 0.0008
-
 9,10-phenanthrenequinone
-
 Homo sapiens
1.1.1.188 0.001
-
 5beta-Androstan-3alpha-ol-17-one
-
 Homo sapiens
1.1.1.188 0.0031
-
 5beta-androstan-3,17-dione
-
 Homo sapiens
1.1.1.188 0.0034
-
 Prostaglandin D2
-
 Homo sapiens
1.1.1.188 0.0774
-
 4-nitrobenzaldehyde
-
 Homo sapiens
1.1.1.188 0.134
-
 (5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.188 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.188 36840
-
 amino acid analysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.188 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.188 lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
-
 Homo sapiens (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
 ?
1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
-
 Homo sapiens (5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+
-
 ?
1.1.1.188 4-nitrobenzaldehyde + NADPH
-
 Homo sapiens 4-nitrobenzyl alcohol + NADP+
-
 ?
1.1.1.188 5beta-androstane-3,17-dione + NADPH
-
 Homo sapiens 5beta-androstan-3alpha-ol-17-one + NADP+
-
 r
1.1.1.188 9,10-phenanthrenequinone + NADPH
-
 Homo sapiens ?
-
 ?
1.1.1.188 prostaglandin H2 + NADPH + H+
-
 Homo sapiens (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.188 8 9 reduction of prostaglandin D2 Homo sapiens
1.1.1.188 9 10 oxidation of 9alpha,11beta-prostaglandin F2 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.188 NADPH
-
 Homo sapiens