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Literature summary extracted from

  • Okuda, A.; Okuda, K.
    Physiological function and kinetic mechanism of human liver alcohol dehydrogenase as 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase (1983), J. Biol. Chem., 258, 2899-2905.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.15 1,10-phenanthroline
-
Homo sapiens
1.14.15.15 Isobutyramide
-
Homo sapiens
1.14.15.15 additional information product inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + reduced adrenodoxin + O2 Homo sapiens
-
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + oxidized adrenodoxin + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.15 Homo sapiens
-
both alcohol:NAD+ oxidoreductase activity, EC 1.1.1.1, and 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity, EC 1.1.1.161, are catalyzed by the same active side of the same enzyme protein
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.15.15
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.15 liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.15.15 0.672
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + reduced adrenodoxin + O2
-
Homo sapiens 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + oxidized adrenodoxin + H2O
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.15.15 10.6
-
-
Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.14.15.15 8.3 11.2 pH 8.3: about 20% of activity maximum, pH 11.2: about 60% of activity maximum Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.15 NAD+
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.15.15 2
-
Isobutyramide
-
Homo sapiens