show Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol
Leinweber, F.J.; Greenough, R.C.; Schwender, C.F.; Kaplan, H.R.; di Carlo, F.J.; Xenobiotica 2, 191-202 (1972)
Data extracted from this reference:
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.160
cytoplasm
-
Homo sapiens
5737
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
Homo sapiens
i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.160
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.160
liver
-
Homo sapiens
-
Storage Stability
EC Number
Storage Stability
Organism
1.1.1.160
-17°C, 4 months, completely stable
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
i.e. bunolol, r, also acts more slowly with NAD+
389408
Homo sapiens
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+
i.e. dihydrobunolol
389408
Homo sapiens
r
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
389408
Homo sapiens
?
-
-
-
-
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.1.1.160
37
-
assay at
Homo sapiens
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.160
6.7
-
assay at
Homo sapiens
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.160
NAD+
slow reaction
Homo sapiens
1.1.1.160
NADP+
-
Homo sapiens
1.1.1.160
NADPH
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.160
NAD+
slow reaction
Homo sapiens
1.1.1.160
NADP+
-
Homo sapiens
1.1.1.160
NADPH
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.160
cytoplasm
-
Homo sapiens
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
Homo sapiens
i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.160
liver
-
Homo sapiens
-
Storage Stability (protein specific)
EC Number
Storage Stability
Organism
1.1.1.160
-17°C, 4 months, completely stable
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
i.e. bunolol, r, also acts more slowly with NAD+
389408
Homo sapiens
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+
i.e. dihydrobunolol
389408
Homo sapiens
r
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
389408
Homo sapiens
?
-
-
-
-
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.1.1.160
37
-
assay at
Homo sapiens
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.160
6.7
-
assay at
Homo sapiens