Data extracted from this reference:
Localization
1.1.1.160
cytoplasm
Homo sapiens
5737
Natural Substrates/ Products (Substrates)
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
Homo sapiens
i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
?
Organism
Source Tissue
1.1.1.160
liver
Homo sapiens
Storage Stability
1.1.1.160
-17°C, 4 months, completely stable
Homo sapiens
Substrates and Products (Substrate)
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
i.e. bunolol, r, also acts more slowly with NAD+
389408
Homo sapiens
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+
i.e. dihydrobunolol
389408
Homo sapiens
r
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
389408
Homo sapiens
?
Temperature Optimum [°C]
1.1.1.160
37
assay at
Homo sapiens
pH Optimum
1.1.1.160
6.7
assay at
Homo sapiens
Cofactor
1.1.1.160
NAD+
slow reaction
Homo sapiens
1.1.1.160
NADP+
Homo sapiens
1.1.1.160
NADPH
Homo sapiens
Cofactor (protein specific)
1.1.1.160
NAD+
slow reaction
Homo sapiens
1.1.1.160
NADP+
Homo sapiens
1.1.1.160
NADPH
Homo sapiens
Localization (protein specific)
1.1.1.160
cytoplasm
Homo sapiens
5737
Natural Substrates/ Products (Substrates) (protein specific)
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
Homo sapiens
i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
?
Source Tissue (protein specific)
1.1.1.160
liver
Homo sapiens
Storage Stability (protein specific)
1.1.1.160
-17°C, 4 months, completely stable
Homo sapiens
Substrates and Products (Substrate) (protein specific)
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
i.e. bunolol, r, also acts more slowly with NAD+
389408
Homo sapiens
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+
i.e. dihydrobunolol
389408
Homo sapiens
r
1.1.1.160
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
389408
Homo sapiens
?
Temperature Optimum [°C] (protein specific)
1.1.1.160
37
assay at
Homo sapiens
pH Optimum (protein specific)
1.1.1.160
6.7
assay at
Homo sapiens