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Literature summary extracted from

  • Rogerson, F.M.; LeHoux, J.G.; Mason, J.I.
    Expression and characterization of isoforms of 3beta-hydroxysteroid dehydrogenase/delta 5->4-isomerase in the hamster (1995), J. Steroid Biochem. Mol. Biol., 55, 481-487.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.145 expression in 293 human fetal kidney cells Cricetinae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.145 0.0024
-
 dehydroepiandrosterone type I Cricetinae
1.1.1.145 0.0029
-
 dehydroepiandrosterone type II Cricetinae
1.1.1.145 0.0055
-
 pregnenolone type I Cricetinae
1.1.1.145 0.0088
-
 pregnenolone type II Cricetinae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 dehydroepiandrosterone + NAD+ Cricetinae
-
 androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD(P)+ Cricetinae
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Cricetinae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 adrenal gland
-
 Cricetinae
-
1.1.1.145 kidney
-
 Cricetinae
-
1.1.1.145 liver male Cricetinae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 dehydroepiandrosterone + NAD+
-
 Cricetinae androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD(P)+
-
 Cricetinae pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
 Cricetinae