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Literature summary extracted from

  • Labrie, F.; Simard, J.; Luu-The, V.; Pelletier, G.; Belanger, A.; Lachance, Y.; Zhao, H.F.; Labrie, C.; Breton, N.; de Launoit, Y.; et al.
    Structure and tissue-specific expression of 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues (1992), J. Steroid Biochem. Mol. Biol., 41, 421-435.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.145 transient expression of HSD I and II cDNA in HeLa cells Homo sapiens
1.1.1.145 transient expression of HSD I and II cDNA in HeLa cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 pregnenolone + NAD(P)+ Homo sapiens
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?
1.1.1.145 pregnenolone + NAD(P)+ Rattus norvegicus
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Homo sapiens
-
-
-
1.1.1.145 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 adipose tissue
-
 Rattus norvegicus
-
1.1.1.145 adrenal gland
-
 Rattus norvegicus
-
1.1.1.145 adrenal gland 3beta-HSD II Homo sapiens
-
1.1.1.145 ovary
-
 Rattus norvegicus
-
1.1.1.145 ovary 3beta-HSD II Homo sapiens
-
1.1.1.145 placenta 3beta-HSD I Homo sapiens
-
1.1.1.145 skin 3beta-HSD I Homo sapiens
-
1.1.1.145 testis
-
 Rattus norvegicus
-
1.1.1.145 testis 3beta-HSD II Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
 Homo sapiens 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
 ?
1.1.1.145 3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
 Rattus norvegicus 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
 ?
1.1.1.145 pregnenolone + NAD(P)+
-
 Homo sapiens pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?
1.1.1.145 pregnenolone + NAD(P)+
-
 Rattus norvegicus pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
 Homo sapiens
1.1.1.145 NAD+
-
 Rattus norvegicus