Literature summary extracted from

Abbaszade, I.G.; Arensburg, J.; Park, C.H.; Kasa-Vubu, J.Z.; Orly, J.; Payne, A.H.
Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancy (1997), Endocrinology, 138, 1392-1399.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.1.1.145	expression of 3beta HSD I, III, IV, V or VI in COS-7 cells	Mus musculus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.1.1.145	0.00004	-	pregnenolone	3betaHSD VI	Mus musculus
1.1.1.145	0.00012	-	dehydroepiandrosterone	3betaHSD VI	Mus musculus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.145	pregnenolone + NAD(P)+	Mus musculus	-	pregn-5-en-3,20-dione + NAD(P)H + H+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.145	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.145	embryo	3betaHSD VI	Mus musculus	-
1.1.1.145	placenta	3betaHSD VI	Mus musculus	-
1.1.1.145	skin	3betaHSD VI	Mus musculus	-
1.1.1.145	testis	3betaHSD I and VI	Mus musculus	-
1.1.1.145	uterus	3betaHSD VI	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.145	3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+	-	Mus musculus	17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H	-	?
1.1.1.145	dehydroepiandrosterone + NAD+	-	Mus musculus	androst-5-en-3,17-dione + NADH + H+	-	?
1.1.1.145	pregnenolone + NAD(P)+	-	Mus musculus	pregn-5-en-3,20-dione + NAD(P)H + H+	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.145	NAD+	-	Mus musculus

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Release 2023.1 (January 2023)