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Literature summary extracted from

  • Pozzi, A.G.; Canosa, L.F.; Calvo, J.C.; Ceballos, N.R.
    Kinetic properties of microsomal 3beta hydroxysteroid dehydrogenase-isomerase from the testis of Bufo arenarum H (2000), J. Steroid Biochem. Mol. Biol., 73, 257-264.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.145 dehydroepiandrosterone 0.01 mM reduced conversion of pregnenolone to 50% Rhinella arenarum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.145 0.00017
-
 dehydroepiandrosterone
-
 Rhinella arenarum
1.1.1.145 0.00102
-
 pregnenolone
-
 Rhinella arenarum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.145 microsome
-
 Rhinella arenarum
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 dehydroepiandrosterone + NAD+ Rhinella arenarum
-
 androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD(P)+ Rhinella arenarum
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Rhinella arenarum
-
 H.
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 testis
-
 Rhinella arenarum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
 Rhinella arenarum 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
 ?
1.1.1.145 dehydroepiandrosterone + NAD+
-
 Rhinella arenarum androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD(P)+
-
 Rhinella arenarum pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
 Rhinella arenarum