Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fahoum, S.K.; Yang, D.C.H.
    Purification of mammalian histidyl-tRNA synthetase and its interaction with myositis-specific anti-Jo-1 antibodies (1987), Biochemistry, 26, 5871-5877.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.21 Myositis-specific anti-Jo-1 autoantibody
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.1.1.21 50000
-
 2 * 50000, SDS-PAGE Rattus norvegicus
6.1.1.21 96000
-
 gel filtration, measurement of the sedimentation coefficient Rattus norvegicus
6.1.1.21 115000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.21 additional information Rattus norvegicus 1. plays an important role in the regulation of protein degradation as well as in protein biosynthesis. 2. involvement of tRNAHis and possibly histidyl-tRNA synthetase in a nonlysosomal ubiquitin-dependent and ATP-dependent protein degradation pathway. 3. involvement in autoimmune diseases ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.21 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.1.1.21
-
 Rattus norvegicus

Renatured (Commentary)

EC Number Renatured (Comment) Organism
6.1.1.21 denaturation with SDS, renatured enzyme shows 10% recovery of activity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.21 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.1.1.21 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.21 ATP + L-histidine + tRNAHis
-
 Rattus norvegicus AMP + diphosphate + L-histidyl-tRNAHis
-
 ?
6.1.1.21 additional information 1. plays an important role in the regulation of protein degradation as well as in protein biosynthesis. 2. involvement of tRNAHis and possibly histidyl-tRNA synthetase in a nonlysosomal ubiquitin-dependent and ATP-dependent protein degradation pathway. 3. involvement in autoimmune diseases Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.1.1.21 dimer 2 * 50000, SDS-PAGE Rattus norvegicus