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Literature summary extracted from

  • Yang, D.C.H.; Dang, C.V.; Arnett, F.C.
    Rat liver histidyl-tRNA synthetase. Purification and inhibition by the myositis-specific anti-Jo-1 autoantibody (1984), Biochem. Biophys. Res. Commun., 120, 15-21.
    View publication on PubMed

Application

EC Number Application Comment Organism
6.1.1.21 medicine purified Jo-1 antigen will be useful in determining the role of anti-Jo-1 in the pathogenesis of polymyositis Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.21 Myositis-specific anti-Jo-1 autoantibody
-
 Homo sapiens
6.1.1.21 Myositis-specific anti-Jo-1 autoantibody
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.1.1.21 64000
-
 2 * 64000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.21 Homo sapiens
-
-
-
6.1.1.21 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.1.1.21
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.21 HeLa cell
-
 Homo sapiens
-
6.1.1.21 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.1.1.21 0.618
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.21 ATP + L-histidine + tRNAHis
-
 Homo sapiens AMP + diphosphate + L-histidyl-tRNAHis
-
 ?
6.1.1.21 ATP + L-histidine + tRNAHis
-
 Rattus norvegicus AMP + diphosphate + L-histidyl-tRNAHis
-
 ?

Subunits

EC Number Subunits Comment Organism
6.1.1.21 dimer 2 * 64000, SDS-PAGE Rattus norvegicus