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Literature summary extracted from

  • Tanabe, T.; Nakanishi, S.; Hashimoto, T.; Ogiwara, H.; Nikawa, J.I.; Numa, S.
    Acetyl-CoA carboxylase from rat liver. EC 6.4.1.2 Acetyl-CoA:carbon-dioxide ligase (ADP-forming) (1981), Methods Enzymol., 71, 5-16.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.4.1.2 citrate nearly absolute requirement for tricarboxylate activators such as citrate or isocitrate Rattus norvegicus
6.4.1.2 isocitrate nearly absolute requirement for tricarboxylate activators such as citrate or isocitrate Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 2-(4-Chlorophenoxy)-2-methylpropionate
-
 Rattus norvegicus
6.4.1.2 2-Methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy]propionic acid
-
 Rattus norvegicus
6.4.1.2 Arachidonoyl-CoA
-
 Rattus norvegicus
6.4.1.2 arachidoyl-CoA
-
 Rattus norvegicus
6.4.1.2 docosanoyl-CoA
-
 Rattus norvegicus
6.4.1.2 Kynurenate
-
 Rattus norvegicus
6.4.1.2 lignoceroyl-CoA
-
 Rattus norvegicus
6.4.1.2 linolenoyl-CoA
-
 Rattus norvegicus
6.4.1.2 linoleoyl-CoA
-
 Rattus norvegicus
6.4.1.2 long-chain acyl-CoA thioesters
-
 Rattus norvegicus
6.4.1.2 myristoyl-CoA
-
 Rattus norvegicus
6.4.1.2 oleoyl-CoA
-
 Rattus norvegicus
6.4.1.2 palmitoleoyl-CoA
-
 Rattus norvegicus
6.4.1.2 palmitoyl-1,N6-etheno-CoA
-
 Rattus norvegicus
6.4.1.2 Palmitoyl-4'-phosphopantetheine
-
 Rattus norvegicus
6.4.1.2 palmitoyl-CoA
-
 Rattus norvegicus
6.4.1.2 palmitoyl-dephospho-CoA
-
 Rattus norvegicus
6.4.1.2 Palmitoyl-inosino-CoA
-
 Rattus norvegicus
6.4.1.2 Palmitoyl-keto-CoA
-
 Rattus norvegicus
6.4.1.2 S-cetyl-CoA
-
 Rattus norvegicus
6.4.1.2 stearoyl-CoA
-
 Rattus norvegicus
6.4.1.2 xanthurenate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.4.1.2 0.015
-
 ATP
-
 Rattus norvegicus
6.4.1.2 0.016
-
 malonyl-CoA
-
 Rattus norvegicus
6.4.1.2 0.025
-
 acetyl-CoA
-
 Rattus norvegicus
6.4.1.2 1.25
-
 acetodethio-CoA
-
 Rattus norvegicus
6.4.1.2 2.5
-
 HCO3- hindlimb muscle Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.2 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.4.1.2 phosphate contains 2.1 mol phosphate per 215000 g of protein Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.4.1.2 230000
-
 x * 230000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.4.1.2
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
6.4.1.2 ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA ordered bi bi uni uni ping-pong mechanism Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.2 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.2 6.05
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetodethio-CoA + HCO3-
-
 Rattus norvegicus ?
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
6.4.1.2 ? x * 230000, SDS-PAGE Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 biotin contains 1 mol of biotin per 237000 g of enzyme Rattus norvegicus