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Literature summary extracted from

  • Ahmad, F.; Ahmad, P.M.
    Acetyl-CoA carboxylase from rat mammary gland (including an additional step yielding fatty acid synthase) (1981), Methods Enzymol., 71, 16-26.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.4.1.2 citrate maximal activation at 25-30 mM Rattus norvegicus
6.4.1.2 citrate completely inactive in absence of the allosteric activator citrate Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 4-bromo-2,3-dioxobutyl-CoA
-
 Rattus norvegicus
6.4.1.2 p-chloromercuribenzoate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.2 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.4.1.2 phosphate contains approximately 6 mol phosphate per 240000 g of protein Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.4.1.2
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.2 mammary gland
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.2 12.2
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
6.4.1.2 20°C, 50 mM imidazole HCl, 0.1 mM EDTA, 0.02% sodium azide, 20% glycerol, 25 mM citrate, pH 7.5, stable for up to 1 week Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
6.4.1.2 ? x * 240000-260000, SDS-PAGE of enzyme dissociated in 1% SDS, 8 M urea and 5 mM DTT Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 biotin contains 1 mol biotin per 240000 g of enzyme Rattus norvegicus