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Literature summary extracted from

  • DeWitt, D.L.; Smith, W.L.
    Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein (1983), J. Biol. Chem., 258, 3285-3293.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.4 13-hydroperoxylinoleic acid 9,11-azoprosta-5,13-dienoic acid prevents inactivation; rapid inactivation of purified enzyme during incubation with prostaglandin H2 Bos taurus
5.3.99.4 9,11-Azoprosta-5,13-dienoic acid
-
 Bos taurus
5.3.99.4 prostaglandin H2 9,11-azoprosta-5,13-dienoic acid prevents inactivation; rapid inactivation of purified enzyme during incubation with prostaglandin H2 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.4 microsome
-
 Bos taurus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.4 52000
-
 x * 52000, SDS-PAGE Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.99.4
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 aorta
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.3.99.4 0.975
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Bos taurus Prostaglandin I2 prostaglandin I2 ?

Subunits

EC Number Subunits Comment Organism
5.3.99.4 ? x * 52000, SDS-PAGE Bos taurus