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Literature summary extracted from
- Tryptophanase: structure, catalytic activities, and mechanism of action (1975), Adv. Enzymol. Relat. Areas Mol. Biol., 42, 287-333.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.99.1 | 4-phenyl-2-aminobutyrate | - |
Escherichia coli |  |
| 4.1.99.1 | beta-phenyllactate | - |
Escherichia coli | |
| 4.1.99.1 | beta-phenylserine | - |
Escherichia coli | |
| 4.1.99.1 | Ethionine | - |
Escherichia coli | |
| 4.1.99.1 | indoleacrylate | - |
Escherichia coli | |
| 4.1.99.1 | indolepropionate | - |
Escherichia coli | |
| 4.1.99.1 | Indolepyruvate | - |
Escherichia coli | |
| 4.1.99.1 | Met | - |
Escherichia coli | |
| 4.1.99.1 | Phe | - |
Aeromonas hydrophila | |
| 4.1.99.1 | Phe | - |
Escherichia coli | |
| 4.1.99.1 | Phe | - |
Providencia rettgeri | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.99.1 | 0.019 | - |
indole | - |
Escherichia coli | |
| 4.1.99.1 | 0.065 | - |
S-benzylcysteine | strain B/1t7-A, 25°C | Escherichia coli | |
| 4.1.99.1 | 0.11 | - |
O-benzylserine | strain B/1t7-A | Escherichia coli | |
| 4.1.99.1 | 0.22 | - |
L-Trp | - |
Aeromonas hydrophila | |
| 4.1.99.1 | 0.26 | - |
L-Trp | - |
Providencia rettgeri | |
| 4.1.99.1 | 0.27 | - |
L-Trp | - |
Paenibacillus alvei | |
| 4.1.99.1 | 0.3 | - |
L-Trp | strain B/1t7-A, 25°C | Escherichia coli | |
| 4.1.99.1 | 0.33 | - |
L-Trp | strain B/1t7-A, 37°C | Escherichia coli | |
| 4.1.99.1 | 0.6 | - |
alpha,beta-diaminopropionic acid | strain B/1t7-A | Escherichia coli | |
| 4.1.99.1 | 1 | - |
S-ethylcysteine | strain B/1t7-A, 25°C | Escherichia coli | |
| 4.1.99.1 | 1.2 | - |
beta-chloroalanine | strain B/1t7-A | Escherichia coli | |
| 4.1.99.1 | 4 | - |
O-methylserine | strain B/1t7-A | Escherichia coli | |
| 4.1.99.1 | 10 | - |
S-methylcysteine | strain B/1t7-A, 37°C | Escherichia coli | |
| 4.1.99.1 | 11 | - |
Cys | - |
Escherichia coli | |
| 4.1.99.1 | 70 | - |
pyruvate | - |
Escherichia coli | |
| 4.1.99.1 | 110 | - |
cysteine sulfinic acid | strain B/1t7-A | Escherichia coli | |
| 4.1.99.1 | 345 | - |
NH4+ | - |
Escherichia coli | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.99.1 | 208000 | - |
- |
Paenibacillus alvei |
| 4.1.99.1 | 220000 | - |
strain B/1t7-A | Escherichia coli |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.99.1 | additional information | Vibrio sp. | - |
? | - |
? | |
| 4.1.99.1 | additional information | Providencia rettgeri | - |
? | - |
? | |
| 4.1.99.1 | additional information | Escherichia coli | induced by Trp | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.99.1 | Aeromonas hydrophila | - |
- |
- |
| 4.1.99.1 | Aeromonas sp. | - |
- |
- |
| 4.1.99.1 | Bacillus sp. (in: Bacteria) | - |
- |
- |
| 4.1.99.1 | Bacteroides sp. | - |
- |
- |
| 4.1.99.1 | Corynebacterium sp. | - |
- |
- |
| 4.1.99.1 | Enterobacter sp. | - |
- |
- |
| 4.1.99.1 | Erwinia sp. | - |
- |
- |
| 4.1.99.1 | Escherichia coli | - |
- |
- |
| 4.1.99.1 | Kluyvera sp. | - |
- |
- |
| 4.1.99.1 | Micrococcus sp. | - |
- |
- |
| 4.1.99.1 | no activity in Acetobacter sp. | - |
- |
- |
| 4.1.99.1 | no activity in Achromobacter sp. | - |
- |
- |
| 4.1.99.1 | no activity in Agrobacterium sp. | - |
- |
- |
| 4.1.99.1 | no activity in Alcaligenes sp. | - |
- |
- |
| 4.1.99.1 | no activity in Azotobacter sp. | - |
- |
- |
| 4.1.99.1 | no activity in Clostridium sp. | - |
- |
- |
| 4.1.99.1 | no activity in Flavobacterium sp. | - |
- |
- |
| 4.1.99.1 | no activity in Mycoplasma sp. | - |
- |
- |
| 4.1.99.1 | no activity in Pseudomonas sp. | - |
- |
- |
| 4.1.99.1 | no activity in Rhizobium sp. | - |
- |
- |
| 4.1.99.1 | no activity in Salmonella sp. | - |
- |
- |
| 4.1.99.1 | no activity in Serratia sp. | - |
- |
- |
| 4.1.99.1 | no activity in Xanthomonas sp. | - |
- |
- |
| 4.1.99.1 | Paenibacillus alvei | - |
- |
- |
| 4.1.99.1 | Paracolobactrum sp. | - |
- |
- |
| 4.1.99.1 | Pasteurella sp. | - |
- |
- |
| 4.1.99.1 | Photobacterium sp. | - |
- |
- |
| 4.1.99.1 | Proteus sp. | - |
- |
- |
| 4.1.99.1 | Providencia rettgeri | - |
- |
- |
| 4.1.99.1 | Sphaerophorus sp. | - |
- |
- |
| 4.1.99.1 | Vibrio sp. | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.99.1 | alpha,beta-diaminopropionic acid | - |
Escherichia coli | ? | - |
? | |
| 4.1.99.1 | beta-chloroalanine + H2O | - |
Escherichia coli | ? | - |
? | |
| 4.1.99.1 | Cys + H2O | - |
Escherichia coli | ? | - |
? | |
| 4.1.99.1 | Cys + H2O | - |
Providencia rettgeri | ? | - |
? | |
| 4.1.99.1 | Cys + indole | - |
Escherichia coli | Trp + ? | - |
? | |
| 4.1.99.1 | cysteine sulfinic acid + H2O | - |
Escherichia coli | ? | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Escherichia coli | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Corynebacterium sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Bacillus sp. (in: Bacteria) | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Aeromonas hydrophila | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Vibrio sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Micrococcus sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Enterobacter sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Aeromonas sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Erwinia sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Proteus sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Bacteroides sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Pasteurella sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Providencia rettgeri | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Paracolobactrum sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Kluyvera sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Photobacterium sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Sphaerophorus sp. | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Paenibacillus alvei | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | additional information | - |
Vibrio sp. | ? | - |
? | |
| 4.1.99.1 | additional information | - |
Providencia rettgeri | ? | - |
? | |
| 4.1.99.1 | additional information | induced by Trp | Escherichia coli | ? | - |
? | |
| 4.1.99.1 | O-benzylserine + H2O | - |
Escherichia coli | ? | - |
? | |
| 4.1.99.1 | O-methylserine + H2O | - |
Escherichia coli | ? | - |
? | |
| 4.1.99.1 | S-benzylcysteine + H2O | - |
Escherichia coli | ? | - |
? | |
| 4.1.99.1 | S-ethylcysteine + H2O | - |
Escherichia coli | ? | - |
? | |
| 4.1.99.1 | S-methyl-L-Cys + H2O | - |
Escherichia coli | ? | - |
? | |
| 4.1.99.1 | S-methyl-L-Cys + H2O | - |
Providencia rettgeri | ? | - |
? | |
| 4.1.99.1 | S-methyl-L-Cys + indole | - |
Escherichia coli | Trp + ? | - |
? | |
| 4.1.99.1 | Ser + H2O | - |
Escherichia coli | ? | - |
? | |
| 4.1.99.1 | Ser + H2O | - |
Providencia rettgeri | ? | - |
? | |
| 4.1.99.1 | Ser + indole | - |
Escherichia coli | Trp + ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.99.1 | More | the dimeric form is not active | Escherichia coli |
| 4.1.99.1 | tetramer | - |
Aeromonas hydrophila |
| 4.1.99.1 | tetramer | - |
Providencia rettgeri |
| 4.1.99.1 | tetramer | - |
Paenibacillus alvei |
| 4.1.99.1 | tetramer | 4 * ? | Escherichia coli |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.99.1 | 7.2 | 8.8 | strain B/1t7-A | Escherichia coli |
| 4.1.99.1 | 7.5 | 8.4 | - |
Paenibacillus alvei |
| 4.1.99.1 | 8 | 9 | - |
Providencia rettgeri |
| 4.1.99.1 | 8.2 | - |
- |
Aeromonas hydrophila |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.99.1 | pyridoxal 5'-phosphate | - |
Vibrio sp. | |
| 4.1.99.1 | pyridoxal 5'-phosphate | some coenzyme analogues can replace pyridoxal 5'-phosphate | Escherichia coli | |
| 4.1.99.1 | pyridoxal 5'-phosphate | one enzyme molecule contains 4 pyridoxal 5'-phosphate combining sites | Escherichia coli | |
| 4.1.99.1 | pyridoxal 5'-phosphate | one enzyme molecule contains 4 pyridoxal 5'-phosphate combining sites | Aeromonas hydrophila | |
| 4.1.99.1 | pyridoxal 5'-phosphate | one enzyme molecule contains 4 pyridoxal 5'-phosphate combining sites | Providencia rettgeri | |
| 4.1.99.1 | pyridoxal 5'-phosphate | one enzyme molecule contains 4 pyridoxal 5'-phosphate combining sites | Paenibacillus alvei | |
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