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Literature summary extracted from

  • Kiick, D.M.; Phillips, R.S.
    Mechanistic deductions from multiple kinetic and solvent deuterium isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Escherichia coli tryptophan indole-lyase (1988), Biochemistry, 27, 7339-7344.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.99.1 Ala competitive Escherichia coli
4.1.99.1 oxindolyl-L-Ala competitive Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.1 Escherichia coli
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.99.1 L-tryptophan + H2O = indole + pyruvate + NH3 mechanism that requires two catalytic bases Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.1 L-Trp + H2O
-
Escherichia coli indole + pyruvate + NH4+
-
?
4.1.99.1 S-methyl-L-Cys + H2O
-
Escherichia coli ?
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.99.1 pyridoxal 5'-phosphate dependent on Escherichia coli