EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.16 | membrane | synaptosomal | Cavia porcellus | 16020 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.16 | additional information | Cavia porcellus | possible implication of the enzyme in the specific degradation of neurotensin and other peptide neurotransmitters in the synaptic cleft | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.16 | Cavia porcellus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.24.16 | - |
Cavia porcellus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.16 | brain | - |
Cavia porcellus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.16 | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | i.e. substance P, cleavage sites: Pro4-Gln5, Gln5-Gln6, Gln6-Phe7 | Cavia porcellus | Arg-Pro-Lys-Pro-Gln + Gln-Phe-Phe-Gly-Leu-Met-NH2 + Arg-Pro-Lys-Pro-Gln-Gln + Phe-Phe-Gly-Leu-Met-NH2 + Arg-Pro-Lys-Pro | - |
? | |
3.4.24.16 | Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O | i.e. bradykinin, cleavage site: Phe5-Ser6 | Cavia porcellus | Arg-Pro-Pro-Gly-Phe + Ser-Pro-Phe-Arg | - |
? | |
3.4.24.16 | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + H2O | i.e. angiotensin I, cleavage site: Pro7-Phe8 | Cavia porcellus | Asp-Arg-Val-Tyr-Ile-His-Pro + Phe-His-Leu | - |
? | |
3.4.24.16 | additional information | marked specificity towards Pro-X bonds present in the interior parts of various neuropeptides and related peptides. No cleavage is observed at the first and second peptide bonds from the NH2-terimini or from the COOH-terminal extension of the peptides examined, suggesting that the enzyme requires both NH2- and COOH-terminal extensions of at least 3 residues from the scissile bond for its action. Not strictly specific for Pro-X bonds | Cavia porcellus | ? | - |
? | |
3.4.24.16 | additional information | possible implication of the enzyme in the specific degradation of neurotensin and other peptide neurotransmitters in the synaptic cleft | Cavia porcellus | ? | - |
? | |
3.4.24.16 | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu + H2O | i.e. neurotensin | Cavia porcellus | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro + Tyr-Ile-Leu | - |
? | |
3.4.24.16 | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu + H2O | specific hydrolysis of the Pro10-Tyr11 bond | Cavia porcellus | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro + Tyr-Ile-Leu | - |
? | |
3.4.24.16 | Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro + H2O | i.e. beta-neoendorphin, cleavage sites: Leu5-Arg6, Arg6-Lys7 | Cavia porcellus | Tyr-Gly-Gly-Phe-Leu + Arg-Lys-Tyr-Pro + Tyr-Gly-Gly-Phe-Leu-Arg + Lys-Tyr-Pro | - |
? | |
3.4.24.16 | Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu + H2O | i.e. BAM-12P, cleavage sites: Phe4-Met5, Arg6-Arg7, Gly9-Arg10 | Cavia porcellus | Tyr-Gly-Gly-Phe + Met-Arg-Arg-Val-Gly + Arg-Pro-Glu + Tyr-Gly-Gly-Phe-Met-Arg + -Arg-Val-Gly | - |
? | |
3.4.24.16 | Tyr-Pro-Phe-Pro-Gly-Pro-Ile + H2O | i.e. beta-casomorphin, cleavage site: Pro4-Gly5 | Cavia porcellus | Tyr-Pro-Phe-Pro + Gly-Pro-Ile | - |
? |