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Literature summary extracted from

  • Orlowski, M.; Michaud, C.; Chu, T.G.
    A soluble metalloendopeptidase from rat brain. Purification of the enzyme and determination of specificity with synthetic and natural peptides (1983), Eur. J. Biochem., 135, 81-88.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.15 1,10-phenanthroline
-
Rattus norvegicus
3.4.24.15 EDTA reactivation by metal ions Rattus norvegicus
3.4.24.15 EGTA
-
Rattus norvegicus
3.4.24.15 NEM
-
Rattus norvegicus
3.4.24.15 PCMB
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.15 0.031
-
benzoyl-Gly-Phe-Phe-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 0.16
-
benzoyl-Gly-Phe-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 0.22
-
tert-butoxycarbonyl-Phe-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 0.24
-
benzoyl-Gly-Lys-Arg-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 0.37
-
benzoyl-Gly-Arg-Ala-Ala-Phe-4-aminobenzoate
-
Rattus norvegicus
3.4.24.15 0.49
-
benzoyl-Gly-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 0.51
-
benzoyl-Gly-Phe-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 0.72
-
benzoyl-Gly-Asp-Ala-Ala-Phe-4-aminobenzoate
-
Rattus norvegicus
3.4.24.15 2
-
benzoyl-Gly-Gly-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 2.5
-
benzoyl-Gly-Ala-Ala-Leu-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 3.1
-
benzoyl-Gly-Ala-Ala-Gly-p-aminobenzoate
-
Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.15 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.15
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.15 brain
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.15 28.7
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.15 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met + H2O cleavage sites: Pro4-Gln5, Phe8-Gly9 and Phe7-Phe8 Rattus norvegicus peptide fragments
-
?
3.4.24.15 Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O i.e. bradykinin, cleavage site: Phe5-Ser6 Rattus norvegicus Arg-Pro-Pro-Gly-Phe + Ser-Pro-Phe-Arg
-
?
3.4.24.15 benzoyl-Arg-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus benzoyl-Arg + Ala-Ala-Phe-p-aminobenzoate
-
?
3.4.24.15 benzoyl-Asp-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus benzoyl-Asp + Ala-Ala-Phe-p-aminobenzoate
-
?
3.4.24.15 benzoyl-Gly-Ala-Ala-Gly-p-aminobenzoate
-
Rattus norvegicus benzoyl-Gly + Ala-Ala-Gly-p-aminobenzoate
-
?
3.4.24.15 benzoyl-Gly-Ala-Ala-Leu-p-aminobenzoate
-
Rattus norvegicus benzoyl-Gly + Ala-Ala-Leu-p-aminobenzoate
-
?
3.4.24.15 benzoyl-Gly-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus benzoyl-Gly + Ala-Ala-Phe-p-aminobenzoate
-
?
3.4.24.15 benzoyl-Gly-Arg-Ala-Ala-Phe-4-aminobenzoate + H2O
-
Rattus norvegicus benzoyl-Gly-Arg + Ala-Ala-Phe-4-aminobenzoate
-
?
3.4.24.15 benzoyl-Gly-Arg-Ala-Ala-Phe-4-aminobenzoate + H2O
-
Rattus norvegicus ?
-
?
3.4.24.15 benzoyl-Gly-Asp-Ala-Ala-Phe-4-aminobenzoate + H2O
-
Rattus norvegicus benzoyl-Gly-Asp + Ala-Ala-Phe-4-aminobenzoate
-
?
3.4.24.15 benzoyl-Gly-Asp-Ala-Ala-Phe-4-aminobenzoate + H2O
-
Rattus norvegicus ?
-
?
3.4.24.15 benzoyl-Gly-Gly-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus benzoyl-Gly + Gly-Ala-Phe-p-aminobenzoate
-
?
3.4.24.15 benzoyl-Gly-Lys-Arg-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus benzoyl-Gly-Lys-Arg + Ala-Ala-Phe-p-aminobenzoate
-
?
3.4.24.15 benzoyl-Gly-Phe-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus benzoyl-Gly-Phe + Ala-Ala-Phe-p-aminobenzoate
-
?
3.4.24.15 benzoyl-Gly-Phe-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus benzoyl-Gly + Phe-Ala-Phe-p-aminobenzoate
-
?
3.4.24.15 benzoyl-Gly-Phe-Phe-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus benzoyl-Gly-Phe-Phe + Ala-Ala-Phe-p-aminobenzoate
-
?
3.4.24.15 luliberin
-
Rattus norvegicus peptide fragments
-
?
3.4.24.15 additional information no hydrolysis of Met-enkephalin Rattus norvegicus ?
-
?
3.4.24.15 pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu
-
Rattus norvegicus pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg + Arg-Pro-Tyr-Ile-Leu
-
?
3.4.24.15 tert-butoxycarbonyl-Phe-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus tert-butoxycarbonyl-Phe + Ala-Ala-Phe-p-aminobenzoate
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.24.15 1.15
-
benzoyl-Gly-Ala-Ala-Gly-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 1.45
-
benzoyl-Gly-Gly-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 2.2
-
benzoyl-Gly-Asp-Ala-Ala-Phe-4-aminobenzoate
-
Rattus norvegicus
3.4.24.15 2.75
-
benzoyl-Gly-Phe-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 3.1
-
benzoyl-Gly-Ala-Ala-Leu-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 4.77
-
benzoyl-Gly-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 5.25
-
benzoyl-Gly-Arg-Ala-Ala-Phe-4-aminobenzoate
-
Rattus norvegicus
3.4.24.15 6.2
-
benzoyl-Gly-Phe-Phe-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 8.6
-
benzoyl-Gly-Phe-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 10.1
-
benzoyl-Gly-Lys-Arg-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus
3.4.24.15 21.5
-
tert-butoxycarbonyl-Phe-Ala-Ala-Phe-p-aminobenzoate
-
Rattus norvegicus