Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Akopyan, T.N.; Couedel, Y.; Orlowski, M.; Fournie-Zaluski, M.C.; Roques, B.P.
    Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15 (1994), Biochem. Biophys. Res. Commun., 198, 787-794.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.15 1,10-phenanthroline
-
 Sus scrofa
3.4.24.15 chymostatin
-
 Sus scrofa
3.4.24.15 Cu2+ 0.1 mM, 90% inhibition Sus scrofa
3.4.24.15 dithiothreitol
-
 Sus scrofa
3.4.24.15 EDTA no inhibition Sus scrofa
3.4.24.15 N-(phenylethylphosphonyl)-Gly-L-Pro-L-aminohexanoic acid
-
 Sus scrofa
3.4.24.15 NEM
-
 Sus scrofa
3.4.24.15 PCMB
-
 Sus scrofa
3.4.24.15 Zn2+ 0.1 mM ZnCl2, complete inhibition Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.15 32.5
-
 propionyl-Gly-Ser-Pro-(farnesyl-Cys)-Val-Leu-Met
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.15 microsome
-
 Sus scrofa
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.15 70000
-
 gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.15 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.15
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.15 brain
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.15 0.00037
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.15 propionyl-Gly-Ser-Pro-(farnesyl-Cys)-Val-Leu-Met
-
 Sus scrofa propionyl-Gly-Ser-Pro-(farnesyl-Cys) + Val-Leu-Met
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.15 6.2 7.5
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.24.15 6 8.5 pH 6.0: about 35% of maximal activity, pH 8.5: about 45% of maximal activity Sus scrofa