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Literature summary extracted from

  • Adhikari, J.; Majumder, A.L.
    L-Myo-inositol-1-phosphate synthase from mammalian brain: partial purification and characterisation of the fetal and adult enzyme (1988), Indian J. Biochem. Biophys., 25, 408-412.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.5.1.4 NH4+ stimulates Homo sapiens
5.5.1.4 NH4+ stimulates Rattus norvegicus
5.5.1.4 NH4+ between 2.5fold and 3fold stimulation in presence of 12 mM NH4Cl Homo sapiens
5.5.1.4 NH4+ between 2.5fold and 3fold stimulation in presence of 12 mM NH4Cl Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.5.1.4 Cu2+
-
 Rattus norvegicus
5.5.1.4 Hg2+
-
 Homo sapiens
5.5.1.4 Hg2+
-
 Rattus norvegicus
5.5.1.4 Li+
-
 Rattus norvegicus
5.5.1.4 Zn2+
-
 Homo sapiens
5.5.1.4 Zn2+
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.5.1.4 4.4
-
 D-glucose 6-phosphate
-
 Homo sapiens
5.5.1.4 4.47
-
 D-glucose 6-phosphate
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.5.1.4 K+ 5 mM KCl stimulates 25-35% Homo sapiens
5.5.1.4 K+ 5 mM KCl stimulates 25-35% Rattus norvegicus
5.5.1.4 Na+
-
 Homo sapiens
5.5.1.4 Na+
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.5.1.4 165000
-
 gel filtration Homo sapiens
5.5.1.4 165000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
5.5.1.4 Homo sapiens
-
-
-
5.5.1.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.5.1.4 partial Homo sapiens
5.5.1.4 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.5.1.4 brain adult Rattus norvegicus
-
5.5.1.4 brain fetal Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.5.1.4 D-Glucose 6-phosphate
-
 Homo sapiens L-myo-Inositol 1-phosphate
-
 ?
5.5.1.4 D-Glucose 6-phosphate
-
 Rattus norvegicus L-myo-Inositol 1-phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5.1.4 7.5
-
-
 Homo sapiens
5.5.1.4 7.5
-
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
5.5.1.4 NAD+ cofactor Homo sapiens
5.5.1.4 NAD+ cofactor Rattus norvegicus