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Literature summary extracted from

  • Baricos, W.H.; Zhou, Y.; Mason, R.W.; Barrett, A.J.
    Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane (1988), Biochem. J., 252, 301-304.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane E-64 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.22.1 0.184
-
 benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
-
 Homo sapiens
3.4.22.1 0.252
-
 benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide
-
 Homo sapiens
3.4.22.15 0.0022
-
 benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.1 Proteins + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Homo sapiens
-
-
-
3.4.22.15 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.15
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.1 kidney
-
 Homo sapiens
-
3.4.22.15 kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
-
 Homo sapiens benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 Proteins + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.15 benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.15 benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.1 dimer 1 * 22000-25000 + 1 * 5000-7000, SDS-PAGE Homo sapiens
3.4.22.15 dimer 1 * 22000-25000 + 1 * 5000-7000, SDS-PAGE under reducing conditions Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.22.1 158
-
 benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
-
 Homo sapiens
3.4.22.1 364
-
 benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide
-
 Homo sapiens
3.4.22.15 25.8
-
 benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.1 6
-
-
 Homo sapiens
3.4.22.15 6
-
 hydrolysis of benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide and benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide Homo sapiens