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Literature summary extracted from

  • Coyette, J.; Perkins, H.R.; Polacheck, I.; Shockman, G.D; Ghuysen, J.M.
    Membrane-bound DD-carboxypeptidase and LD-transpeptidase of Streptococcus faecalis ATCC 9790 (1974), Eur. J. Biochem., 44, 459-468.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.16.4 benzylpenicillin
-
 Enterococcus faecalis
3.4.16.4 cephalexin
-
 Enterococcus faecalis
3.4.16.4 FeSO4
-
 Enterococcus faecalis
3.4.16.4 Penicillin V
-
 Enterococcus faecalis
3.4.16.4 Zn2+
-
 Enterococcus faecalis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.16.4 1.45
-
 Nalpha-(beta-1,4 acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)L-Lys-D-Ala-D-Ala
-
 Enterococcus faecalis
3.4.16.4 3.8
-
 Nalpha,Nepsilon-Diacetyl-L-Lys-D-Ala-D-Ala
-
 Enterococcus faecalis
3.4.16.4 7.5
-
 acetyl-L-Ala-D-Glu-L-Lys(Ac)-D-Ala-D-Ala
-
 Enterococcus faecalis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.16.4 membrane
-
 Enterococcus faecalis 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Enterococcus faecalis
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.16.4 Enterococcus faecalis
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.16.4 additional information
-
-
 Enterococcus faecalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.16.4 acetyl-L-Ala-D-Glu-L-Lys(Ac)-D-Ala-D-Ala + H2O
-
 Enterococcus faecalis acetyl-L-Ala-D-Glu-L-Lys(Ac)-D-Ala + D-Ala
-
 ?
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + Gly-Gly acceptors in transpeptidase reaction Enterococcus faecalis Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-Gly-Gly + D-Ala
-
 ?
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O
-
 Enterococcus faecalis Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-alanine
-
 ?
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-Gly + H2O
-
 Enterococcus faecalis Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + Gly
-
 ?
3.4.16.4 Nalpha-(beta-1,4 acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)L-Lys-D-Ala-D-Ala + H2O
-
 Enterococcus faecalis Nalpha-(beta-1,4 acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)L-Lys-D-Ala + D-Ala
-
 ?
3.4.16.4 Nalpha-(beta-1,4-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)-L-lysyl-D-alanyl-D-alanine + H2O
-
 Enterococcus faecalis Nalpha-(beta-1,4-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)-L-lysyl-D-alanine + D-alanine
-
 ?
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Enterococcus faecalis ?
-
 ?
3.4.16.4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Enterococcus faecalis UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.16.4 6
-
 sodium cacodylate buffer Enterococcus faecalis
3.4.16.4 7
-
 sodium barbital buffer Enterococcus faecalis