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Literature summary extracted from

  • Augustyns, K.; Bal, G.; Thonus, G.; Belyaev, A.; Zhang, X.M.; Bollaert, W.; Lambeir, A.M.; Durinx, C.; Goossens, F.; Haemers, A.
    The unique properties of dipeptidyl-peptidase IV (DPP IV / CD26) and the therapeutic potential of DPP IV inhibitors (1999), Curr. Med. Chem., 6, 311-327.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.5 additional information therapeutical perspectives for dipeptidyl peptidase IV inhibitors Homo sapiens
3.4.14.5 additional information
-
 Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.14.5 membrane
-
 Mammalia 16020
-
3.4.14.5 membrane anchored Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.14.5 additional information Homo sapiens on human T cells the enzyme has been demonstrated to be a functional collagen receptor leading to cell activation. The enzyme may be important in modulation of the biological activity on some of the cytokines, growth factors and neuropeptides. CD/DPP IV plays a role in HIV infection, but the exact mechanism remains to be elucidated ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Homo sapiens
-
-
-
3.4.14.5 Mammalia
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 beta-casomorphin + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 beta-casomorphin + H2O Tyr-Pro-/-Phe-Pro-/-Gly Mammalia ?
-
 ?
3.4.14.5 enterostatin + H2O i.e. Val-Pro-/-Asn-Pro-/-Arg Mammalia ?
-
 ?
3.4.14.5 human glucagon-like peptide 1 (7-36) + H2O i.e. His-Ala-/-Glu-Gly-Thr-Phe-Thr-Ser-Asp Mammalia ?
-
 ?
3.4.14.5 human glucagon-like peptide 2 + H2O i.e. His-Ala-/-Asp-Gly-Ser-Phe-Ser-Asp-Glu Mammalia ?
-
 ?
3.4.14.5 human glucose-dependent insulinotropic polypeptide + H2O i.e. Tyr-Ala-/-Glu-Gly-Thr-Phe-Thr-Ser-Asp- Mammalia ?
-
 ?
3.4.14.5 human growth hormone-releasing factor + H2O i.e. Tyr-Ala-/-Asp-Ala-Ile-Phe-Thr-Asn-Ser- Mammalia ?
-
 ?
3.4.14.5 human neuropeptide Y + H2O i.e. Tyr-Pro-/-Ser-Lys-Pro-Asp-Asn-Pro-Gly Mammalia Tyr-Pro + Ser-Lys-Pro-Asp-Asn-Pro-Gly
-
 ?
3.4.14.5 human peptide YY + H2O i.e. Tyr-Pro-/-Ile-Lys-Pro-Glu-Ala-Pro-Gly- Mammalia Tyr-Pro + Ile-Lys-Pro-Glu-Ala-Pro-Gly-
-
 ?
3.4.14.5 additional information on human T cells the enzyme has been demonstrated to be a functional collagen receptor leading to cell activation. The enzyme may be important in modulation of the biological activity on some of the cytokines, growth factors and neuropeptides. CD/DPP IV plays a role in HIV infection, but the exact mechanism remains to be elucidated Homo sapiens ?
-
 ?
3.4.14.5 substance P + H2O
-
 Homo sapiens Arg-Pro + Lys-Pro + ?
-
 ?
3.4.14.5 substance P + H2O Arg-Pro-/-Lys-Pro-/-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 Mammalia Arg-Pro + Lys-Pro + ?
-
 ?
3.4.14.5 Tyr-Pro-Phe-Pro-NH2 + H2O i.e. morphiceptin Mammalia Tyr-Pro + Phe-Pro-NH2
-
 ?