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Literature summary extracted from

  • Püschel, G.; Mentlein, R.; Heymann, E.
    Isolation and characterization of dipeptidyl peptidase IV from human placenta (1982), Eur. J. Biochem., 126, 359-365.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.5 2-mercaptoethanol
-
 Homo sapiens
3.4.14.5 bis-(4-nitrophenylphosphate)
-
 Homo sapiens
3.4.14.5 diisopropyl fluorophosphate
-
 Homo sapiens
3.4.14.5 Zn2+ 1 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.5 0.016
-
 Lys-Pro-4-methoxy-2-naphthylamide
-
 Homo sapiens
3.4.14.5 0.018
-
 Gly-Pro-4-methoxy-2-naphthylamide
-
 Homo sapiens
3.4.14.5 0.019
-
 Phe-Pro-2-naphthylamide
-
 Homo sapiens
3.4.14.5 0.02
-
 Phe-Ala-Pro-2-naphthylamide
-
 Homo sapiens
3.4.14.5 1
-
 Ala-Ala-2-naphthylamide
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.14.5 microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.14.5 120000
-
 x * 120000, SDS-PAGE Homo sapiens
3.4.14.5 200000
-
 above, gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.14.5 side-chain modification glycoprotein Homo sapiens
3.4.14.5 side-chain modification 30% carbohydrate Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.14.5
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.5 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 Ala-Ala-2-naphthylamide + H2O
-
 Homo sapiens Ala-Ala + 2-naphthylamine
-
 ?
3.4.14.5 casomorphin + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 Gly-Hyp-Ala + H2O
-
 Homo sapiens Ala + ?
-
 ?
3.4.14.5 Gly-Pro-2-naphthylamide + H2O
-
 Homo sapiens Gly-Pro + 2-naphthylamine
-
 ?
3.4.14.5 Gly-Pro-4-methoxy-2-naphthylamide + H2O
-
 Homo sapiens Gly-Pro + 4-methoxy-2-naphthylamine
-
 ?
3.4.14.5 His-Pro-Phe + H2O
-
 Homo sapiens His-Pro + Phe
-
 ?
3.4.14.5 kentsin + H2O
-
 Homo sapiens Thr-Pro + ?
-
 ?
3.4.14.5 Lys-Pro-4-methoxy-2-naphthylamide + H2O
-
 Homo sapiens Lys-Pro + 4-methoxy-2-naphthylamine
-
 ?
3.4.14.5 Phe-Ala-Pro-2-naphthylamide + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 Phe-Pro-2-naphthylamide + H2O L-Phe-L-Pro-2-naphthylamide Homo sapiens Phe-Pro + 2-naphthylamine
-
 ?
3.4.14.5 Pro-Pro-Gly + H2O
-
 Homo sapiens Gly + ?
-
 ?
3.4.14.5 substance P + H2O
-
 Homo sapiens Arg-Pro + Lys-Pro + ?
-
 ?
3.4.14.5 synthetic renin inhibitor + H2O His-Pro-Phe-His-Leu-D-Leu-Val-Tyr Homo sapiens ?
-
 ?
3.4.14.5 Tyr-D-Ala-Gly-Phe-Met-NH2 + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.14.5 ? x * 120000, SDS-PAGE Homo sapiens
3.4.14.5 dimer
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.5 8.5
-
 hydrolysis of Gly-Pro-2-naphthylamide Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.14.5 7 9.6 pH 7.0: about 45% of maximal activity, pH 9.6: about 90% of maximal activity, hydrolysis of Gly-Pro-2-naphthylamide Homo sapiens