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Literature summary extracted from

  • McDonald, J.K.; Zeitman, B.B.; Reilly, T.J.; Ellis, S.
    New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones (1969), J. Biol. Chem., 244, 2693-2709.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.1 additional information
-
 additional information
-
 Rattus norvegicus
3.4.14.1 additional information
-
 additional information
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.14.1 Br- absolute requirement for halide ions, the efficacy in decreasing order: Cl-, Br-, I-, F- Rattus norvegicus
3.4.14.1 Cl-
-
 Bos taurus
3.4.14.1 Cl- absolute requirement for halide ions, the efficacy in decreasing order: Cl-, Br-, I-, F- Rattus norvegicus
3.4.14.1 F- absolute requirement for halide ions, the efficacy in decreasing order: Cl-, Br-, I-, F- Rattus norvegicus
3.4.14.1 I- absolute requirement for halide ions, the efficacy in decreasing order: Cl-, Br-, I-, F- Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.1 Bos taurus
-
-
-
3.4.14.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.1 liver
-
 Rattus norvegicus
-
3.4.14.1 spleen
-
 Rattus norvegicus
-
3.4.14.1 spleen
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.1 4 Gly-L-Phe-NH2 + 4 H2O polymerization Bos taurus Gly-Phe-Gly-Phe-Gly-Phe-Gly-Phe-NH2 + 3 NH3
-
 ?
3.4.14.1 5 Gly-Arg-2-naphthylamide + 5 H2O polymerization Bos taurus (Gly-Arg-)5-2-naphthylamide + 4 2-naphthylamine polymers up to (Gly-Arg-)5-2-naphthylamide ?
3.4.14.1 beta-corticotropin + H2O
-
 Rattus norvegicus Ser-Tyr + Ser-Met + Glu-His + Phe-Arg + Trp-Gly
-
 ?
3.4.14.1 beta-corticotropin + H2O
-
 Bos taurus Ser-Tyr + Ser-Met + Glu-His + Phe-Arg + Trp-Gly further degradation of corticotropin is prevented by a penultimate prolyl residue ?
3.4.14.1 Gly-Arg-NH2 + H2O polymerization Bos taurus ?
-
 ?
3.4.14.1 Gly-Gly-Gly + H2O
-
 Bos taurus Gly-Gly + Gly
-
 ?
3.4.14.1 Gly-Trp-NH2 + H2O polymerization Bos taurus ?
-
 ?
3.4.14.1 hexaalanine + H2O
-
 Bos taurus Ala-Ala
-
 ?
3.4.14.1 Insulin B-chain + H2O bovine, oxidized Rattus norvegicus ?
-
 ?
3.4.14.1 Insulin B-chain + H2O bovine, oxidized Bos taurus ?
-
 ?
3.4.14.1 Met-Met-Met + H2O
-
 Bos taurus Met-Met + Met
-
 ?
3.4.14.1 pentaalanine + H2O
-
 Bos taurus Ala-Ala + Ala-Ala-Ala tri-alanine is resistant to further breakdown ?
3.4.14.1 Phe-Phe-Phe + H2O
-
 Bos taurus Phe-Phe + Phe
-
 ?
3.4.14.1 Ser-His-Ala + H2O
-
 Bos taurus Ser-His + Ala
-
 ?
3.4.14.1 Ser-Met-Glu + H2O
-
 Bos taurus Ser-Met + Glu
-
 ?
3.4.14.1 tetraglycine + H2O
-
 Bos taurus Gly-Gly
-
 ?
3.4.14.1 tetraphenylalanine + H2O
-
 Bos taurus Phe-Phe
-
 ?