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Literature summary extracted from

  • Stach, D.; Zheng, Y.F.; Perez, A.L.; Oehlschlager, A.C.; Abe, I.; Prestwich, G.D.; Hartman, P.G.
    Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase (1997), J. Med. Chem., 40, 201-209.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.7 Sulfur-substituted squalene oxide analogues mechanism-based inhibition Candida albicans
5.4.99.7 Sulfur-substituted squalene oxide analogues mechanism-based inhibition Rattus norvegicus
5.4.99.7 Sulfur-substituted squalene oxide analogues mechanism-based inhibition Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Candida albicans
-
-
-
5.4.99.7 Rattus norvegicus
-
-
-
5.4.99.7 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.99.7 liver
-
Rattus norvegicus
-
5.4.99.7 liver
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.7 (S)-squalene-2,3-epoxide
-
Rattus norvegicus Lanosterol
-
?
5.4.99.7 (S)-squalene-2,3-epoxide
-
Sus scrofa Lanosterol
-
?
5.4.99.7 (S)-squalene-2,3-epoxide
-
Candida albicans Lanosterol
-
?