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Literature summary extracted from
- Properties of Nalpha-acetylhistidine deacetylase in brain of rainbow trout Oncorhynchus mykiss (1993), Comp. Biochem. Physiol. B, 106, 309-315.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.13.5 | 1,10-phenanthroline | - |
Oncorhynchus mykiss |  |
| 3.4.13.5 | ATP | - |
Oncorhynchus mykiss | |
| 3.4.13.5 | bestatin | 0.01 mM, 15% inhibition of the enzyme from eye, 1% inhibition of the enzyme from brain | Oncorhynchus mykiss | |
| 3.4.13.5 | CoA | - |
Oncorhynchus mykiss | |
| 3.4.13.5 | Cu2+ | - |
Oncorhynchus mykiss | |
| 3.4.13.5 | EDTA | - |
Oncorhynchus mykiss | |
| 3.4.13.5 | Hg2+ | - |
Oncorhynchus mykiss | |
| 3.4.13.5 | Pb2+ | - |
Oncorhynchus mykiss | |
| 3.4.13.5 | PCMB | - |
Oncorhynchus mykiss | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.5 | 55000 | - |
2 * 55000, SDS-PAGE | Oncorhynchus mykiss |
| 3.4.13.5 | 120000 | - |
brain and eye enzyme, gel filtration | Oncorhynchus mykiss |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.13.5 | Oncorhynchus mykiss | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.13.5 | - |
Oncorhynchus mykiss |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.13.5 | brain | all regions of the brain except for the spinal cord and the optic nerve | Oncorhynchus mykiss | - |
| 3.4.13.5 | eye | - |
Oncorhynchus mykiss | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.5 | 1.03 | - |
brain | Oncorhynchus mykiss |
| 3.4.13.5 | 1.27 | - |
eye | Oncorhynchus mykiss |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.13.5 | anserine + H2O | 16% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | beta-Ala + 1-methylhistidine | - |
? | |
| 3.4.13.5 | carnosine + H2O | 83% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | ? | - |
? | |
| 3.4.13.5 | Gly-Gly + H2O | 385% of the activity with N-acetyl-L-His | Oncorhynchus mykiss | Gly + Gly | - |
? | |
| 3.4.13.5 | Gly-L-His + H2O | 110% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | Gly + L-His | - |
? | |
| 3.4.13.5 | Gly-L-Leu + H2O | 832% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | Gly + L-Leu | - |
? | |
| 3.4.13.5 | homocarnosine + H2O | 67% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | ? | - |
? | |
| 3.4.13.5 | L-Ala-L-His + H2O | 105% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | L-Ala + L-His | - |
? | |
| 3.4.13.5 | L-Leu-Gly + H2O | 101% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | L-Leu + Gly | - |
? | |
| 3.4.13.5 | N-acetyl-L-Glu + H2O | 23% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | L-Glu + acetate | - |
? | |
| 3.4.13.5 | N-acetyl-L-His + H2O | - |
Oncorhynchus mykiss | His + acetate | - |
? | |
| 3.4.13.5 | N-acetyl-L-Leu + H2O | 110% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | L-Leu + acetate | - |
? | |
| 3.4.13.5 | N-acetyl-L-methionine + H2O | 254% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | L-Met + acetate | - |
? | |
| 3.4.13.5 | N-acetyl-L-Trp + H2O | 30% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | L-Trp + acetate | - |
? | |
| 3.4.13.5 | Nalpha-chloroacetyl-L-Leu + H2O | 1235% of the activity with N-acetyl-L-His, brain enzyme | Oncorhynchus mykiss | L-Leu + chloroacetate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.13.5 | dimer | 2 * 55000, SDS-PAGE | Oncorhynchus mykiss |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.5 | 50 | - |
- |
Oncorhynchus mykiss |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.5 | 10 | 60 | 10°C: about 50% of maximal activity, brain and eye enzyme, 60°C, about 40% of maximal activity, brain enzyme, 60°C: about 90% of maximal activity, eye enzyme | Oncorhynchus mykiss |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.5 | 6 | 6.5 | - |
Oncorhynchus mykiss |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.5 | 5 | 9 | less than 10% of maximal activity at pH 5.0 and 9.0 | Oncorhynchus mykiss |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.5 | 5.2 | 8.1 | maximal stability | Oncorhynchus mykiss |
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