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Literature summary extracted from
- Characterization of dipeptidyl and tripeptidyl aminopeptidases in human kidney soluble fraction (1991), Clin. Chim. Acta, 196, 135-142.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.14.2 | analysis | the enzyme is a potential urinary marker for the biochemical detection of kidney damage | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.4 | bestatin | - |
Homo sapiens |  |
| 3.4.11.4 | Cd2+ | - |
Homo sapiens | |
| 3.4.11.4 | Cu2+ | - |
Homo sapiens | |
| 3.4.11.4 | Hg2+ | - |
Homo sapiens | |
| 3.4.11.4 | N-ethylmaleimide | - |
Homo sapiens | |
| 3.4.11.4 | p-Hydroxymercuriphenyl sulfonate | - |
Homo sapiens | |
| 3.4.11.4 | puromycin | - |
Homo sapiens | |
| 3.4.11.4 | Zn2+ | - |
Homo sapiens | |
| 3.4.14.1 | leupeptin | - |
Homo sapiens | |
| 3.4.14.1 | NEM | - |
Homo sapiens | |
| 3.4.14.1 | p-Hydroxymercuriphenyl sulfonate | - |
Homo sapiens | |
| 3.4.14.2 | Cd2+ | - |
Homo sapiens | |
| 3.4.14.2 | Co2+ | - |
Homo sapiens | |
| 3.4.14.2 | Cu2+ | - |
Homo sapiens | |
| 3.4.14.2 | Hg2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.14.1 | 210000 | - |
- |
Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.4 | Homo sapiens | - |
- |
- |
| 3.4.14.1 | Homo sapiens | - |
- |
- |
| 3.4.14.2 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.11.4 | - |
Homo sapiens |
| 3.4.14.1 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.11.4 | kidney | - |
Homo sapiens | - |
| 3.4.14.1 | kidney | - |
Homo sapiens | - |
| 3.4.14.2 | kidney | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.4 | Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.14.1 | Gly-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | Gly-Arg + 7-amino-4-methylcoumarin | - |
? | |
| 3.4.14.2 | Lys-Ala-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | Lys-Ala + 7-amino-4-methylcoumarin | - |
? | |
| 3.4.14.2 | Phe-Pro-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | Phe-Pro + 7-amino-4-methylcoumarin | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.4 | 7.5 | - |
- |
Homo sapiens |
| 3.4.14.1 | 6 | - |
- |
Homo sapiens |
| 3.4.14.2 | 5.5 | - |
- |
Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.14.1 | 4 | 7.5 | 50% of maximal activity at pH 4.0 and at pH 7.5 | Homo sapiens |
| 3.4.14.2 | 4 | 7 | 50% of maximal activity at pH 4 and 7 | Homo sapiens |
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Release 2023.1 (January 2023)
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