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Literature summary extracted from
- Aminopeptidasen und Aminosaeurearylamidasen (1974), Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. ), 1, 987-1015.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.1 | CN- | - |
Bos taurus |  |
| 3.4.11.1 | CN- | - |
Brassica sp. | |
| 3.4.11.1 | CN- | - |
Oryctolagus cuniculus | |
| 3.4.11.1 | CN- | - |
Proteus vulgaris | |
| 3.4.11.1 | CN- | - |
Rattus norvegicus | |
| 3.4.11.1 | CN- | - |
Sus scrofa | |
| 3.4.11.1 | CN- | - |
trout | |
| 3.4.11.1 | Cu2+ | - |
Bos taurus | |
| 3.4.11.1 | Cu2+ | - |
Brassica sp. | |
| 3.4.11.1 | Cu2+ | - |
Homo sapiens | |
| 3.4.11.1 | Cu2+ | - |
Oryctolagus cuniculus | |
| 3.4.11.1 | Cu2+ | - |
Proteus vulgaris | |
| 3.4.11.1 | Cu2+ | - |
Rattus norvegicus | |
| 3.4.11.1 | Cu2+ | - |
Sus scrofa | |
| 3.4.11.1 | Cu2+ | - |
trout | |
| 3.4.11.1 | Fe2+ | - |
Bos taurus | |
| 3.4.11.1 | Fe2+ | - |
Brassica sp. | |
| 3.4.11.1 | Fe2+ | - |
Oryctolagus cuniculus | |
| 3.4.11.1 | Fe2+ | - |
Proteus vulgaris | |
| 3.4.11.1 | Fe2+ | - |
Rattus norvegicus | |
| 3.4.11.1 | Fe2+ | - |
Sus scrofa | |
| 3.4.11.1 | Fe2+ | - |
trout | |
| 3.4.11.1 | Fe3+ | - |
Bos taurus | |
| 3.4.11.1 | Fe3+ | - |
Brassica sp. | |
| 3.4.11.1 | Fe3+ | - |
Oryctolagus cuniculus | |
| 3.4.11.1 | Fe3+ | - |
Proteus vulgaris | |
| 3.4.11.1 | Fe3+ | - |
Rattus norvegicus | |
| 3.4.11.1 | Fe3+ | - |
Sus scrofa | |
| 3.4.11.1 | Fe3+ | - |
trout | |
| 3.4.11.1 | Hg2+ | - |
Bos taurus | |
| 3.4.11.1 | Hg2+ | - |
Brassica sp. | |
| 3.4.11.1 | Hg2+ | - |
Oryctolagus cuniculus | |
| 3.4.11.1 | Hg2+ | - |
Proteus vulgaris | |
| 3.4.11.1 | Hg2+ | - |
Rattus norvegicus | |
| 3.4.11.1 | Hg2+ | - |
Sus scrofa | |
| 3.4.11.1 | Hg2+ | - |
trout | |
| 3.4.11.1 | P2O4- | - |
Bos taurus | |
| 3.4.11.1 | P2O4- | - |
Brassica sp. | |
| 3.4.11.1 | P2O4- | - |
Oryctolagus cuniculus | |
| 3.4.11.1 | P2O4- | - |
Proteus vulgaris | |
| 3.4.11.1 | P2O4- | - |
Rattus norvegicus | |
| 3.4.11.1 | P2O4- | - |
Sus scrofa | |
| 3.4.11.1 | P2O4- | - |
trout | |
| 3.4.11.1 | Pb2+ | - |
Bos taurus | |
| 3.4.11.1 | Pb2+ | - |
Brassica sp. | |
| 3.4.11.1 | Pb2+ | - |
Oryctolagus cuniculus | |
| 3.4.11.1 | Pb2+ | - |
Proteus vulgaris | |
| 3.4.11.1 | Pb2+ | - |
Rattus norvegicus | |
| 3.4.11.1 | Pb2+ | - |
Sus scrofa | |
| 3.4.11.1 | Pb2+ | - |
trout | |
| 3.4.11.1 | SH- | - |
Bos taurus | |
| 3.4.11.1 | SH- | - |
Brassica sp. | |
| 3.4.11.1 | SH- | - |
Oryctolagus cuniculus | |
| 3.4.11.1 | SH- | - |
Proteus vulgaris | |
| 3.4.11.1 | SH- | - |
Rattus norvegicus | |
| 3.4.11.1 | SH- | - |
Sus scrofa | |
| 3.4.11.1 | SH- | - |
trout | |
| 3.4.11.1 | Zn2+ | - |
Bos taurus | |
| 3.4.11.1 | Zn2+ | - |
Brassica sp. | |
| 3.4.11.1 | Zn2+ | - |
Oryctolagus cuniculus | |
| 3.4.11.1 | Zn2+ | - |
Proteus vulgaris | |
| 3.4.11.1 | Zn2+ | - |
Rattus norvegicus | |
| 3.4.11.1 | Zn2+ | - |
Sus scrofa | |
| 3.4.11.1 | Zn2+ | - |
trout | |
| 3.4.11.3 | 8-hydroxyquinoline | - |
Homo sapiens | |
| 3.4.11.3 | Co2+ | at high concentration inhibition | Homo sapiens | |
| 3.4.11.3 | Cu2+ | - |
Homo sapiens | |
| 3.4.11.3 | cysteine | - |
Homo sapiens | |
| 3.4.11.3 | EDTA | - |
Homo sapiens | |
| 3.4.11.3 | Fe2+ | - |
Homo sapiens | |
| 3.4.11.3 | HCO3- | - |
Homo sapiens | |
| 3.4.11.3 | Mn2+ | at high concentration inhibition | Homo sapiens | |
| 3.4.11.3 | Ni2+ | - |
Homo sapiens | |
| 3.4.11.3 | Pb2+ | - |
Homo sapiens | |
| 3.4.11.3 | S-benzylcysteine | and S-benzylcysteine containing peptides | Homo sapiens | |
| 3.4.11.3 | Zn2+ | - |
Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.1 | Mg2+ | activation | Homo sapiens | |
| 3.4.11.1 | Mg2+ | activation | Rattus norvegicus | |
| 3.4.11.1 | Mg2+ | activation | Sus scrofa | |
| 3.4.11.1 | Mg2+ | activation | Bos taurus | |
| 3.4.11.1 | Mg2+ | activation | Oryctolagus cuniculus | |
| 3.4.11.1 | Mg2+ | activation | Proteus vulgaris | |
| 3.4.11.1 | Mg2+ | activation | Brassica sp. | |
| 3.4.11.1 | Mg2+ | activation | trout | |
| 3.4.11.1 | Mn2+ | activation | Homo sapiens | |
| 3.4.11.1 | Mn2+ | activation | Rattus norvegicus | |
| 3.4.11.1 | Mn2+ | activation | Sus scrofa | |
| 3.4.11.1 | Mn2+ | activation | Bos taurus | |
| 3.4.11.1 | Mn2+ | activation | Oryctolagus cuniculus | |
| 3.4.11.1 | Mn2+ | activation | Proteus vulgaris | |
| 3.4.11.1 | Mn2+ | activation | Brassica sp. | |
| 3.4.11.1 | Mn2+ | activation | trout | |
| 3.4.11.3 | Co2+ | inhibition at high concentration | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.1 | Bos taurus | - |
- |
- |
| 3.4.11.1 | Brassica sp. | - |
- |
- |
| 3.4.11.1 | Homo sapiens | - |
- |
- |
| 3.4.11.1 | Oryctolagus cuniculus | - |
- |
- |
| 3.4.11.1 | Proteus vulgaris | - |
- |
- |
| 3.4.11.1 | Rattus norvegicus | - |
- |
- |
| 3.4.11.1 | Sus scrofa | - |
hog | - |
| 3.4.11.1 | trout | - |
- |
- |
| 3.4.11.3 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.11.1 | heart | - |
Homo sapiens | - |
| 3.4.11.1 | heart | - |
Rattus norvegicus | - |
| 3.4.11.1 | heart | - |
Oryctolagus cuniculus | - |
| 3.4.11.1 | kidney | - |
Homo sapiens | - |
| 3.4.11.1 | kidney | - |
Sus scrofa | - |
| 3.4.11.1 | lens | - |
Bos taurus | - |
| 3.4.11.1 | liver | - |
Homo sapiens | - |
| 3.4.11.1 | liver | - |
Sus scrofa | - |
| 3.4.11.1 | liver | - |
Bos taurus | - |
| 3.4.11.1 | lung | - |
Bos taurus | - |
| 3.4.11.1 | muscle | - |
Homo sapiens | - |
| 3.4.11.1 | muscle | - |
Rattus norvegicus | - |
| 3.4.11.1 | muscle | - |
Oryctolagus cuniculus | - |
| 3.4.11.1 | serum | - |
Rattus norvegicus | - |
| 3.4.11.1 | serum | - |
Sus scrofa | - |
| 3.4.11.1 | serum | - |
Bos taurus | - |
| 3.4.11.1 | serum | - |
Oryctolagus cuniculus | - |
| 3.4.11.1 | serum | - |
Proteus vulgaris | - |
| 3.4.11.1 | serum | - |
trout | - |
| 3.4.11.1 | small intestine | - |
Rattus norvegicus | - |
| 3.4.11.1 | small intestine | - |
Sus scrofa | - |
| 3.4.11.1 | small intestine | - |
trout | - |
| 3.4.11.3 | erythrocyte | - |
Homo sapiens | - |
| 3.4.11.3 | kidney | - |
Homo sapiens | - |
| 3.4.11.3 | liver | - |
Homo sapiens | - |
| 3.4.11.3 | mammary gland | - |
Homo sapiens | - |
| 3.4.11.3 | ovary | - |
Homo sapiens | - |
| 3.4.11.3 | pancreas | - |
Homo sapiens | - |
| 3.4.11.3 | placenta | - |
Homo sapiens | - |
| 3.4.11.3 | serum | of pregnant women | Homo sapiens | - |
| 3.4.11.3 | urine | - |
Homo sapiens | - |
| 3.4.11.3 | uterus | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.1 | additional information | - |
assay methods | Rattus norvegicus |
| 3.4.11.1 | additional information | - |
assay methods | Sus scrofa |
| 3.4.11.1 | additional information | - |
assay methods | Bos taurus |
| 3.4.11.1 | additional information | - |
assay methods | Oryctolagus cuniculus |
| 3.4.11.1 | additional information | - |
assay methods | Proteus vulgaris |
| 3.4.11.1 | additional information | - |
assay methods | Brassica sp. |
| 3.4.11.1 | additional information | - |
assay methods | trout |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.1 | amino acid amides + H2O | fast hydrolysis: L-Leu | Homo sapiens | amino acid + NH3 | - |
? | |
| 3.4.11.1 | amino acid amides + H2O | fast hydrolysis: L-Leu | Rattus norvegicus | amino acid + NH3 | - |
? | |
| 3.4.11.1 | amino acid amides + H2O | fast hydrolysis: L-Leu | Sus scrofa | amino acid + NH3 | - |
? | |
| 3.4.11.1 | amino acid amides + H2O | fast hydrolysis: L-Leu | Bos taurus | amino acid + NH3 | - |
? | |
| 3.4.11.1 | amino acid amides + H2O | fast hydrolysis: L-Leu | Oryctolagus cuniculus | amino acid + NH3 | - |
? | |
| 3.4.11.1 | amino acid amides + H2O | fast hydrolysis: L-Leu | Proteus vulgaris | amino acid + NH3 | - |
? | |
| 3.4.11.1 | amino acid amides + H2O | fast hydrolysis: L-Leu | Brassica sp. | amino acid + NH3 | - |
? | |
| 3.4.11.1 | amino acid amides + H2O | fast hydrolysis: L-Leu | trout | amino acid + NH3 | - |
? | |
| 3.4.11.1 | L-amino acid-peptide + H2O | Leu-Gly | Rattus norvegicus | amino acid + peptide | - |
? | |
| 3.4.11.1 | L-amino acid-peptide + H2O | Leu-Gly | Sus scrofa | amino acid + peptide | - |
? | |
| 3.4.11.1 | L-amino acid-peptide + H2O | Leu-Gly | Bos taurus | amino acid + peptide | - |
? | |
| 3.4.11.1 | L-amino acid-peptide + H2O | Leu-Gly | Oryctolagus cuniculus | amino acid + peptide | - |
? | |
| 3.4.11.1 | L-amino acid-peptide + H2O | Leu-Gly | Proteus vulgaris | amino acid + peptide | - |
? | |
| 3.4.11.1 | L-amino acid-peptide + H2O | Leu-Gly | Brassica sp. | amino acid + peptide | - |
? | |
| 3.4.11.1 | L-amino acid-peptide + H2O | Leu-Gly | trout | amino acid + peptide | - |
? | |
| 3.4.11.3 | oxytocin + H2O | - |
Homo sapiens | acyclic peptide + H2O | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.1 | 8.5 | 10 | - |
Rattus norvegicus |
| 3.4.11.1 | 8.5 | 10 | - |
Sus scrofa |
| 3.4.11.1 | 8.5 | 10 | - |
Bos taurus |
| 3.4.11.1 | 8.5 | 10 | - |
Oryctolagus cuniculus |
| 3.4.11.1 | 8.5 | 10 | - |
Proteus vulgaris |
| 3.4.11.1 | 8.5 | 10 | - |
Brassica sp. |
| 3.4.11.1 | 8.5 | 10 | - |
trout |
| 3.4.11.3 | 7 | 7.7 | depending on substrate | Homo sapiens |
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