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Literature summary extracted from

  • Yamamoto, S.; Lin, K.; Bloch, K.
    Some properties of the microsomal 2,3-oxidosqualene sterol cyclase (1969), Proc. Natl. Acad. Sci. USA, 63, 110-117.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.4.99.7 deoxycholate the effective concentration range for enzyme activation is extremely narrow, around 0.1%. The enzyme activity may depend not only on the final concentration of sodium deoxycholate but also on its ratio to protein Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.7 additional information in solutions of low ionic strength the enzyme polymerizes to an inactive form Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.4.99.7 0.025
-
 2,3-epoxysqualene
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.4.99.7 microsome
-
 Sus scrofa
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.4.99.7 90000
-
 gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Sus scrofa
-
 hog
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.99.7 partial Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.99.7 liver
-
 Sus scrofa
-

Storage Stability

EC Number Storage Stability Organism
5.4.99.7 -70°C, stable for at least several months Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Sus scrofa Lanosterol
-
 ?