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Literature summary extracted from

  • Gray, G.M.; Santiago, N.A.
    Intestinal surface amino-oligopeptidases. I. Isolation of two weight isomers and their subunits from rat brush border (1977), J. Biol. Chem., 252, 4922-4928.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 Co2+ slight inhibition Rattus norvegicus
3.4.11.2 EDTA
-
 Rattus norvegicus
3.4.11.2 Mg2+ slight inhibition Rattus norvegicus
3.4.11.2 Mn2+ slight inhibition Rattus norvegicus
3.4.11.2 Zn2+ slight inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 membrane brush border membrane Rattus norvegicus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.11.2 71000
-
 alpha,beta, 2 * 91000 + 2 * 71000, enzyme I, SDS-PAGE Rattus norvegicus
3.4.11.2 91000
-
 alpha,beta, 2 * 91000 + 2 * 71000, enzyme I, SDS-PAGE Rattus norvegicus
3.4.11.2 91000
-
 2 * 91000, enzyme II Rattus norvegicus
3.4.11.2 180000
-
 enzyme II, PAGE Rattus norvegicus
3.4.11.2 320000
-
 enzyme I, PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.2 aminoacyl peptide Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.11.2 side-chain modification
-
 Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.2
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 aminoacyl peptide
-
 Rattus norvegicus ?
-
 ?
3.4.11.2 Leu-2-naphthylamide + H2O
-
 Rattus norvegicus Leu + 2-naphthylamine
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.11.2 dimer 2 * 91000, enzyme II Rattus norvegicus
3.4.11.2 tetramer alpha,beta, 2 * 91000 + 2 * 71000, enzyme I, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.2 7.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.11.2 7 8 90% of maximal activity at pH 7.0 and pH 8.0 Rattus norvegicus