Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Luciani, N.; Marie-Claire, C.; Ruffet, E.; Beaumont, A.; Roques, B.P.; Fournie-Zaluski, M.C.
    Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): insights into its mechanism of action (1998), Biochemistry, 37, 686-692.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.2
-
 Sus scrofa

Protein Variants

EC Number Protein Variants Comment Organism
3.4.11.2 E350A inactive Sus scrofa
3.4.11.2 E350D reduced activity Sus scrofa
3.4.11.2 E350Q reduced activity Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 1,10-phenanthroline
-
 Homo sapiens
3.4.11.2 1,10-phenanthroline
-
 Sus scrofa
3.4.11.2 bestatin
-
 Homo sapiens
3.4.11.2 bestatin
-
 Sus scrofa
3.4.11.2 hydroxamate RB 38A
-
 Sus scrofa
3.4.11.2 phosphinopeptides
-
 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.2 Zn2+
-
 Homo sapiens
3.4.11.2 Zn2+
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.2 aminoacyl peptide Homo sapiens
-
 ?
-
 ?
3.4.11.2 aminoacyl peptide Sus scrofa
-
 ?
-
 ?
3.4.11.2 enkephalin Sus scrofa
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Homo sapiens
-
-
-
3.4.11.2 Sus scrofa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 Ala-p-nitroanilide + H2O
-
 Sus scrofa Ala + p-nitroaniline
-
 ?
3.4.11.2 aminoacyl peptide
-
 Homo sapiens ?
-
 ?
3.4.11.2 aminoacyl peptide
-
 Sus scrofa ?
-
 ?
3.4.11.2 enkephalin
-
 Sus scrofa ?
-
 ?
3.4.11.2 Leu5-enkephalin + H2O
-
 Sus scrofa tyrosin + (2-5)Leu5-enkephalin
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.11.2 33.2
-
 Leu5-enkephalin
-
 Sus scrofa