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Literature summary extracted from
- Catalytic properties and distribution profiles of paraoxonase and cholinesterase phenotypes in human sera (1995), Toxicol. Lett., 82/83, 447-452.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.1.8.1 | medicine | enzymic activities in patiens with dementia or hyperlipidaemia | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | EDTA | - |
Homo sapiens |  |
| 3.1.1.8 | 4,4'-Bipyridine | competitive, reversible | Homo sapiens | |
| 3.1.1.8 | HI 6 | competitive, reversible | Homo sapiens | |
| 3.1.1.8 | additional information | enzyme variants usual, fluoride resistant, and atypical differ in rates of inhibition by the charged organophosphates and carbamates | Homo sapiens | |
| 3.1.1.8 | PAM-2 | competitive, reversible | Homo sapiens | |
| 3.1.1.8 | phosphostigmine | competitive, reversible | Homo sapiens | |
| 3.1.1.8 | Ro 02-0683 | progressive inhibitor | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.8 | 0.56 | - |
acetylthiocholine | usual variant | Homo sapiens | |
| 3.1.1.8 | 0.57 | - |
propionylthiocholine | atypical variant | Homo sapiens | |
| 3.1.1.8 | 0.7 | - |
propionylthiocholine | fluoride resistant variant | Homo sapiens | |
| 3.1.1.8 | 0.71 | - |
acetylthiocholine | fluoride resistant variant | Homo sapiens | |
| 3.1.1.8 | 0.76 | - |
propionylthiocholine | usual variant | Homo sapiens | |
| 3.1.1.8 | 0.96 | - |
acetylthiocholine | atypical variant | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | Homo sapiens | - |
- |
- |
| 3.1.1.8 | Homo sapiens | - |
- |
- |
| 3.1.8.1 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.2 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | serum | - |
Homo sapiens | - |
| 3.1.1.8 | serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.2 | 2-naphthyl acetate + H2O | - |
Homo sapiens | 2-naphthol + acetate | - |
? | |
| 3.1.1.2 | phenyl acetate + H2O | - |
Homo sapiens | phenol + acetate | - |
? | |
| 3.1.1.8 | acetylthiocholine + H2O | - |
Homo sapiens | acetate + thiocholine | - |
? | |
| 3.1.1.8 | propionylthiocholine + H2O | propylthiocholine | Homo sapiens | propanoate + thiocholine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.8 | butyrylcholinesterase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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