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Literature summary extracted from

  • Zhao, Y.; Abend, A.; Kunz, M.; Such.P.; Retey, J.
    Electron paramagnetic resonance studies of the methylmalonyl-CoA mutase reaction (1994), Eur. J. Biochem., 225, 891-896.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.2 3-carboxypropyl-CoA
-
 Propionibacterium freudenreichii subsp. shermanii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.4.99.2 0.025
-
 succinyl-CoA
-
 Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 0.132
-
 4-Carboxy-2-oxobutanoyl-CoA
-
 Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 0.136
-
 methylmalonyl-carba(dethia)-coenzyme A succinyl-carba(dethia)-CoA Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 2.2
-
 succinyl-dicarba(dethia)-CoA
-
 Propionibacterium freudenreichii subsp. shermanii

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.2 Propionibacterium freudenreichii subsp. shermanii
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
5.4.99.2 (R)-methylmalonyl-CoA = succinyl-CoA evidence for radical intermediates Propionibacterium freudenreichii subsp. shermanii
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.2 (R)-2-methylmalonyl-CoA
-
 Propionibacterium freudenreichii subsp. shermanii succinyl-CoA
-
 ?
5.4.99.2 4-Carboxy-2-oxobutanoyl-CoA
-
 Propionibacterium freudenreichii subsp. shermanii ?
-
 ?
5.4.99.2 methylmalonyl-carba(dethia)-coenzyme A
-
 Propionibacterium freudenreichii subsp. shermanii succinyl-carby(dethia)-CoA
-
 ?
5.4.99.2 Succinyl-carba(dethia)-CoA
-
 Propionibacterium freudenreichii subsp. shermanii ?
-
 ?
5.4.99.2 Succinyl-dicarba(dethia)-CoA
-
 Propionibacterium freudenreichii subsp. shermanii ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.99.2 cobamide dependent on Propionibacterium freudenreichii subsp. shermanii