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Literature summary extracted from

  • Fruton, J.S.
    Pepsin (1971), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 3, 119-164.
No PubMed abstract available

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.23.1
-
Sus scrofa
3.4.23.1
-
Scombridae gen. sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.1 amylopectin sulfate
-
dogfish
3.4.23.1 amylopectin sulfate
-
Gallus gallus
3.4.23.1 amylopectin sulfate
-
salmon
3.4.23.1 amylopectin sulfate
-
Scombridae gen. sp.
3.4.23.1 amylopectin sulfate
-
shark
3.4.23.1 amylopectin sulfate
-
Sus scrofa
3.4.23.1 Bis-(beta-chloroethyl)sulfide
-
dogfish
3.4.23.1 Bis-(beta-chloroethyl)sulfide
-
Gallus gallus
3.4.23.1 Bis-(beta-chloroethyl)sulfide
-
salmon
3.4.23.1 Bis-(beta-chloroethyl)sulfide
-
Scombridae gen. sp.
3.4.23.1 Bis-(beta-chloroethyl)sulfide
-
shark
3.4.23.1 Bis-(beta-chloroethyl)sulfide
-
Sus scrofa
3.4.23.1 I2
-
dogfish
3.4.23.1 I2
-
Gallus gallus
3.4.23.1 I2
-
salmon
3.4.23.1 I2
-
Scombridae gen. sp.
3.4.23.1 I2
-
shark
3.4.23.1 imidazole hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced dogfish
3.4.23.1 imidazole hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced Gallus gallus
3.4.23.1 imidazole hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced salmon
3.4.23.1 imidazole hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced Scombridae gen. sp.
3.4.23.1 imidazole hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced shark
3.4.23.1 imidazole hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced Sus scrofa
3.4.23.1 KCN similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced dogfish
3.4.23.1 KCN similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced Gallus gallus
3.4.23.1 KCN similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced salmon
3.4.23.1 KCN similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced Scombridae gen. sp.
3.4.23.1 KCN similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced shark
3.4.23.1 KCN similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced Sus scrofa
3.4.23.1 additional information diazoketones; ketenes dogfish
3.4.23.1 additional information diazoketones; ketenes Gallus gallus
3.4.23.1 additional information diazoketones; ketenes salmon
3.4.23.1 additional information diazoketones; ketenes Scombridae gen. sp.
3.4.23.1 additional information diazoketones; ketenes shark
3.4.23.1 additional information diazoketones; ketenes Sus scrofa
3.4.23.1 N-bromosuccinimide
-
dogfish
3.4.23.1 N-bromosuccinimide
-
Gallus gallus
3.4.23.1 N-bromosuccinimide
-
salmon
3.4.23.1 N-bromosuccinimide
-
Scombridae gen. sp.
3.4.23.1 N-bromosuccinimide
-
shark
3.4.23.1 N-bromosuccinimide
-
Sus scrofa
3.4.23.1 p-bromophenylacyl bromide
-
dogfish
3.4.23.1 p-bromophenylacyl bromide
-
Gallus gallus
3.4.23.1 p-bromophenylacyl bromide
-
salmon
3.4.23.1 p-bromophenylacyl bromide
-
Scombridae gen. sp.
3.4.23.1 p-bromophenylacyl bromide
-
shark
3.4.23.1 p-bromophenylacyl bromide
-
Sus scrofa
3.4.23.1 peptides 29 amino acid peptide liberated in activation of pepsinogen dogfish
3.4.23.1 peptides 29 amino acid peptide liberated in activation of pepsinogen Gallus gallus
3.4.23.1 peptides 29 amino acid peptide liberated in activation of pepsinogen salmon
3.4.23.1 peptides 29 amino acid peptide liberated in activation of pepsinogen Scombridae gen. sp.
3.4.23.1 peptides 29 amino acid peptide liberated in activation of pepsinogen shark
3.4.23.1 peptides 29 amino acid peptide liberated in activation of pepsinogen Sus scrofa
3.4.23.1 poly-L-lysine
-
dogfish
3.4.23.1 poly-L-lysine
-
Gallus gallus
3.4.23.1 poly-L-lysine
-
salmon
3.4.23.1 poly-L-lysine
-
Scombridae gen. sp.
3.4.23.1 poly-L-lysine
-
shark
3.4.23.1 poly-L-lysine
-
Sus scrofa
3.4.23.1 Tetranitromethane similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced dogfish
3.4.23.1 Tetranitromethane similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced Gallus gallus
3.4.23.1 Tetranitromethane similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced salmon
3.4.23.1 Tetranitromethane similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced Scombridae gen. sp.
3.4.23.1 Tetranitromethane similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced shark
3.4.23.1 Tetranitromethane similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.23.1 additional information
-
additional information
-
Gallus gallus
3.4.23.1 additional information
-
additional information
-
Sus scrofa
3.4.23.1 additional information
-
additional information
-
salmon
3.4.23.1 additional information
-
additional information
-
shark
3.4.23.1 additional information
-
additional information
-
Scombridae gen. sp.
3.4.23.1 additional information
-
additional information
-
dogfish

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.23.1 additional information
-
-
Gallus gallus
3.4.23.1 additional information
-
-
Sus scrofa
3.4.23.1 additional information
-
-
salmon
3.4.23.1 additional information
-
-
shark
3.4.23.1 additional information
-
-
Scombridae gen. sp.
3.4.23.1 additional information
-
-
dogfish

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.1 Proteins + H2O Gallus gallus enzyme formed from pepsinogen A, agent of gastric digestion in mammals and birds ?
-
?
3.4.23.1 Proteins + H2O Gallus gallus preferential cleavage: Phe-, Leu- ?
-
?
3.4.23.1 Proteins + H2O Sus scrofa preferential cleavage: Phe-, Leu- ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.1 dogfish
-
-
-
3.4.23.1 Gallus gallus
-
-
-
3.4.23.1 salmon
-
-
-
3.4.23.1 Scombridae gen. sp.
-
-
-
3.4.23.1 shark
-
-
-
3.4.23.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.1 gastric mucosa
-
Sus scrofa
-
3.4.23.1 gastric mucosa
-
Scombridae gen. sp.
-
3.4.23.1 gastric mucosa
-
dogfish
-
3.4.23.1 stomach
-
Gallus gallus
-
3.4.23.1 stomach
-
salmon
-
3.4.23.1 stomach
-
shark
-
3.4.23.1 stomach
-
Scombridae gen. sp.
-
3.4.23.1 stomach
-
dogfish
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.1 benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O
-
Gallus gallus benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester
-
?
3.4.23.1 benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O
-
Sus scrofa benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester
-
?
3.4.23.1 benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O
-
salmon benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester
-
?
3.4.23.1 benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O
-
shark benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester
-
?
3.4.23.1 benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O
-
Scombridae gen. sp. benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester
-
?
3.4.23.1 benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O
-
dogfish benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester
-
?
3.4.23.1 Hemoglobin + H2O
-
Gallus gallus ?
-
?
3.4.23.1 Hemoglobin + H2O
-
Sus scrofa ?
-
?
3.4.23.1 Hemoglobin + H2O
-
Scombridae gen. sp. ?
-
?
3.4.23.1 Hemoglobin + H2O
-
dogfish ?
-
?
3.4.23.1 additional information transpeptidation reactions Gallus gallus ?
-
?
3.4.23.1 additional information transpeptidation reactions Sus scrofa ?
-
?
3.4.23.1 additional information transpeptidation reactions salmon ?
-
?
3.4.23.1 additional information transpeptidation reactions shark ?
-
?
3.4.23.1 additional information transpeptidation reactions Scombridae gen. sp. ?
-
?
3.4.23.1 additional information transpeptidation reactions dogfish ?
-
?
3.4.23.1 additional information absolute requirement for L-enantiomer in both the X and Y position of substrate Gallus gallus ?
-
?
3.4.23.1 additional information absolute requirement for L-enantiomer in both the X and Y position of substrate Sus scrofa ?
-
?
3.4.23.1 additional information absolute requirement for L-enantiomer in both the X and Y position of substrate salmon ?
-
?
3.4.23.1 additional information absolute requirement for L-enantiomer in both the X and Y position of substrate shark ?
-
?
3.4.23.1 additional information absolute requirement for L-enantiomer in both the X and Y position of substrate Scombridae gen. sp. ?
-
?
3.4.23.1 additional information absolute requirement for L-enantiomer in both the X and Y position of substrate dogfish ?
-
?
3.4.23.1 additional information condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products Gallus gallus ?
-
?
3.4.23.1 additional information condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products Sus scrofa ?
-
?
3.4.23.1 additional information condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products salmon ?
-
?
3.4.23.1 additional information condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products shark ?
-
?
3.4.23.1 additional information condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products Scombridae gen. sp. ?
-
?
3.4.23.1 additional information condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products dogfish ?
-
?
3.4.23.1 additional information side chain specificity Gallus gallus ?
-
?
3.4.23.1 additional information side chain specificity Sus scrofa ?
-
?
3.4.23.1 additional information side chain specificity salmon ?
-
?
3.4.23.1 additional information side chain specificity shark ?
-
?
3.4.23.1 additional information side chain specificity Scombridae gen. sp. ?
-
?
3.4.23.1 additional information side chain specificity dogfish ?
-
?
3.4.23.1 additional information organic sulfites Gallus gallus ?
-
?
3.4.23.1 additional information organic sulfites Sus scrofa ?
-
?
3.4.23.1 additional information organic sulfites salmon ?
-
?
3.4.23.1 additional information organic sulfites shark ?
-
?
3.4.23.1 additional information organic sulfites Scombridae gen. sp. ?
-
?
3.4.23.1 additional information organic sulfites dogfish ?
-
?
3.4.23.1 Proteins + H2O enzyme formed from pepsinogen A, agent of gastric digestion in mammals and birds Gallus gallus ?
-
?
3.4.23.1 Proteins + H2O preferential cleavage: Phe-, Leu- Gallus gallus ?
-
?
3.4.23.1 Proteins + H2O preferential cleavage: Phe-, Leu- Sus scrofa ?
-
?
3.4.23.1 serum albumin + H2O
-
dogfish ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.23.1 37
-
assay at Gallus gallus
3.4.23.1 37
-
assay at Sus scrofa
3.4.23.1 37
-
assay at salmon
3.4.23.1 37
-
assay at shark
3.4.23.1 37
-
assay at Scombridae gen. sp.
3.4.23.1 37
-
assay at dogfish

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.23.1 additional information
-
additional information
-
Sus scrofa
3.4.23.1 additional information
-
additional information
-
salmon
3.4.23.1 additional information
-
additional information
-
shark
3.4.23.1 additional information
-
additional information
-
Scombridae gen. sp.
3.4.23.1 additional information
-
additional information
-
dogfish

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.23.1 additional information
-
-
Gallus gallus
3.4.23.1 additional information
-
-
Sus scrofa
3.4.23.1 additional information
-
-
salmon
3.4.23.1 additional information
-
-
shark
3.4.23.1 additional information
-
-
Scombridae gen. sp.
3.4.23.1 additional information
-
-
dogfish
3.4.23.1 2
-
-
Gallus gallus
3.4.23.1 2
-
-
salmon
3.4.23.1 2
-
-
shark
3.4.23.1 2
-
-
Scombridae gen. sp.
3.4.23.1 2
-
-
dogfish
3.4.23.1 3.5
-
-
Gallus gallus
3.4.23.1 3.5
-
-
salmon
3.4.23.1 3.5
-
-
shark
3.4.23.1 3.5
-
-
Scombridae gen. sp.
3.4.23.1 3.5
-
-
dogfish

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.23.1 additional information
-
-
Gallus gallus
3.4.23.1 additional information
-
-
Sus scrofa
3.4.23.1 additional information
-
-
salmon
3.4.23.1 additional information
-
-
shark
3.4.23.1 additional information
-
-
Scombridae gen. sp.
3.4.23.1 additional information
-
-
dogfish

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.23.1 additional information
-
autolytic degradation in acid solution Sus scrofa