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Literature summary extracted from

  • Sellers, V.M.; Dailey, H.A.
    Expression, purification, and characterization of recombinant mammalian ferrochelatase (1997), Methods Enzymol., 281, 378-387.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.98.1.1 overexpression in Escherichia coli Mus musculus
4.98.1.1 overexpression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.98.1.1 Cd2+
-
 Homo sapiens
4.98.1.1 Cd2+
-
 Mus musculus
4.98.1.1 Hg2+
-
 Homo sapiens
4.98.1.1 Hg2+
-
 Mus musculus
4.98.1.1 Mn2+
-
 Homo sapiens
4.98.1.1 Mn2+
-
 Mus musculus
4.98.1.1 N-alkylated porphyrins
-
 Homo sapiens
4.98.1.1 N-alkylated porphyrins
-
 Mus musculus
4.98.1.1 Pb2+
-
 Homo sapiens
4.98.1.1 Pb2+
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.98.1.1 0.00819
-
 protoporphyrin
-
 Homo sapiens
4.98.1.1 0.00935
-
 protoporphyrin
-
 Homo sapiens
4.98.1.1 0.0111
-
 Fe2+
-
 Mus musculus
4.98.1.1 0.0153
-
 protoporphyrin
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.98.1.1 protoporphyrin IX + Fe2+ Mus musculus final step of heme biosynthesis ?
-
 ?
4.98.1.1 protoporphyrin IX + Fe2+ Homo sapiens final step of heme biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.98.1.1 Homo sapiens
-
-
-
4.98.1.1 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.98.1.1 deuteroporphyrin + Fe2+
-
 Mus musculus deuteroheme + 2 H+
-
 ?
4.98.1.1 deuteroporphyrin + Fe2+
-
 Homo sapiens deuteroheme + 2 H+
-
 ?
4.98.1.1 Fe2+-hematoporphyrin
-
 Mus musculus ?
-
 ?
4.98.1.1 Fe2+-hematoporphyrin
-
 Homo sapiens ?
-
 ?
4.98.1.1 mesoporphyrin + Fe2+
-
 Mus musculus mesoheme + H+
-
 ?
4.98.1.1 mesoporphyrin + Fe2+
-
 Homo sapiens mesoheme + H+
-
 ?
4.98.1.1 protoporphyrin + Fe2+
-
 Mus musculus protoheme + 2 H+
-
 ?
4.98.1.1 protoporphyrin + Fe2+
-
 Homo sapiens protoheme + 2 H+
-
 ?
4.98.1.1 protoporphyrin + Zn2+
-
 Homo sapiens Zn2+-protoporphyrin + H+
-
 ?
4.98.1.1 protoporphyrin IX + Fe2+ final step of heme biosynthesis Mus musculus ?
-
 ?
4.98.1.1 protoporphyrin IX + Fe2+ final step of heme biosynthesis Homo sapiens ?
-
 ?