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Literature summary extracted from

  • Dailey, H.A.; Sellers, V.M.; Dailey, T.A.
    Mammalian ferrochelatase. Expression and characterization of normal and two human protoporphyric ferrochelatases (1994), J. Biol. Chem., 269, 390-395.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
4.98.1.1 F417S less than 2% of normal activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.98.1.1 0.01
-
 Fe2+
-
 Homo sapiens
4.98.1.1 0.0111
-
 Fe2+
-
 Mus musculus
4.98.1.1 0.0153
-
 protoporphyrin
-
 Mus musculus
4.98.1.1 0.0168
-
 protoporphyrin
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.98.1.1 mitochondrion
-
 Mus musculus 5739
-
4.98.1.1 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.98.1.1 protoporphyrin IX + Fe2+ Mus musculus final step of heme biosynthesis ?
-
 ?
4.98.1.1 protoporphyrin IX + Fe2+ Homo sapiens final step of heme biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.98.1.1 Homo sapiens
-
-
-
4.98.1.1 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.98.1.1 expressed in Escherichia coli Mus musculus
4.98.1.1 expressed in Escherichia coli Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.98.1.1 protoporphyrin + Fe2+
-
 Mus musculus protoheme + 2 H+
-
 ?
4.98.1.1 protoporphyrin + Fe2+
-
 Homo sapiens protoheme + 2 H+
-
 ?
4.98.1.1 protoporphyrin IX + Fe2+ final step of heme biosynthesis Mus musculus ?
-
 ?
4.98.1.1 protoporphyrin IX + Fe2+ final step of heme biosynthesis Homo sapiens ?
-
 ?