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Literature summary extracted from
- The biochemistry and enzymology of amino acid dehydrogenases (1994), Crit. Rev. Biochem. Mol. Biol., 29, 415-467.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.1.1 | L-Ala | - |
Anabaena cylindrica |  |
| 1.4.1.1 | L-Ala | - |
Bacillus licheniformis | |
| 1.4.1.1 | L-Ala | reductive amination of pyruvate | Kitasatospora aureofaciens | |
| 1.4.1.1 | L-Ala | - |
Pseudomonas sp. | |
| 1.4.1.1 | Mercurials | - |
Anabaena cylindrica | |
| 1.4.1.1 | Mercurials | - |
Bacillus subtilis | |
| 1.4.1.1 | Mercurials | - |
Lysinibacillus sphaericus | |
| 1.4.1.1 | Mercurials | - |
Mycobacterium tuberculosis |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.1.1 | 0.023 | - |
NADH | - |
Bacillus subtilis | |
| 1.4.1.1 | 0.029 | - |
NADH | - |
Kitasatospora aureofaciens | |
| 1.4.1.1 | 0.031 | - |
NADH | - |
Halobacterium salinarum | |
| 1.4.1.1 | 0.035 | - |
NADH | - |
Bacillus subtilis | |
| 1.4.1.1 | 0.035 | - |
NADH | - |
Thermus thermophilus | |
| 1.4.1.1 | 0.037 | - |
NADH | - |
Bacillus cereus | |
| 1.4.1.1 | 0.059 | - |
NADH | - |
Pseudomonas sp. | |
| 1.4.1.1 | 0.086 | - |
NADH | - |
Bacillus japonicum | |
| 1.4.1.1 | 0.11 | - |
NAD+ | - |
Kitasatospora aureofaciens | |
| 1.4.1.1 | 0.11 | - |
pyruvate | - |
Anabaena cylindrica | |
| 1.4.1.1 | 0.12 | - |
NAD+ | - |
Thermus thermophilus | |
| 1.4.1.1 | 0.18 | - |
NAD+ | - |
Bacillus subtilis | |
| 1.4.1.1 | 0.18 | - |
NAD+ | - |
Bacillus cereus | |
| 1.4.1.1 | 0.18 | - |
L-Ala | - |
Thermus thermophilus | |
| 1.4.1.1 | 0.2 | - |
NAD+ | - |
Bacillus japonicum | |
| 1.4.1.1 | 0.2 | - |
NADH | - |
Halobacterium salinarum | |
| 1.4.1.1 | 0.48 | - |
pyruvate | - |
Bacillus cereus | |
| 1.4.1.1 | 0.49 | - |
pyruvate | - |
Bacillus japonicum | |
| 1.4.1.1 | 0.5 | - |
NAD+ | - |
Halobacterium salinarum | |
| 1.4.1.1 | 0.54 | - |
pyruvate | - |
Bacillus subtilis | |
| 1.4.1.1 | 0.56 | - |
pyruvate | - |
Kitasatospora aureofaciens | |
| 1.4.1.1 | 0.75 | - |
pyruvate | - |
Thermus thermophilus | |
| 1.4.1.1 | 0.8 | - |
pyruvate | - |
Halobacterium salinarum | |
| 1.4.1.1 | 0.82 | - |
NH4+ | - |
Halobacterium salinarum | |
| 1.4.1.1 | 0.95 | - |
pyruvate | - |
Halobacterium salinarum | |
| 1.4.1.1 | 1 | - |
L-Ala | - |
Bacillus japonicum | |
| 1.4.1.1 | 1.5 | - |
NAD+ | - |
Halobacterium salinarum | |
| 1.4.1.1 | 1.73 | - |
L-Ala | - |
Bacillus subtilis | |
| 1.4.1.1 | 4.3 | - |
pyruvate | - |
Pseudomonas sp. | |
| 1.4.1.1 | 5 | - |
L-Ala | - |
Kitasatospora aureofaciens | |
| 1.4.1.1 | 5.3 | - |
L-Ala | - |
Halobacterium salinarum | |
| 1.4.1.1 | 6.67 | - |
NH4+ | - |
Kitasatospora aureofaciens | |
| 1.4.1.1 | 7 | - |
L-Ala | - |
Halobacterium salinarum | |
| 1.4.1.1 | 8 | - |
NH4+ | - |
Anabaena cylindrica | |
| 1.4.1.1 | 8.9 | - |
NH4+ | - |
Bacillus japonicum | |
| 1.4.1.1 | 12.5 | - |
L-Ala | - |
Bacillus cereus | |
| 1.4.1.1 | 26 | - |
NH4+ | - |
Pseudomonas sp. | |
| 1.4.1.1 | 30 | - |
NH4+ | - |
Bacillus cereus | |
| 1.4.1.1 | 38 | - |
NH4+ | - |
Bacillus subtilis | |
| 1.4.1.1 | 38 | - |
NH4+ | - |
Lysinibacillus sphaericus | |
| 1.4.1.1 | 59 | - |
NH3 | - |
Thermus thermophilus | |
| 1.4.1.1 | 500 | - |
NH4+ | - |
Halobacterium salinarum | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.4.1.1 | 190000 | - |
- |
Bacillus japonicum |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.1.1 | Anabaena cylindrica | - |
- |
- |
| 1.4.1.1 | Bacillus cereus | - |
- |
- |
| 1.4.1.1 | Bacillus japonicum | - |
- |
- |
| 1.4.1.1 | Bacillus licheniformis | - |
- |
- |
| 1.4.1.1 | Bacillus subtilis | - |
- |
- |
| 1.4.1.1 | Geobacillus stearothermophilus | - |
- |
- |
| 1.4.1.1 | Halobacterium salinarum | - |
- |
- |
| 1.4.1.1 | Kitasatospora aureofaciens | - |
- |
- |
| 1.4.1.1 | Lysinibacillus sphaericus | - |
- |
- |
| 1.4.1.1 | Mycobacterium tuberculosis | - |
- |
- |
| 1.4.1.1 | Pseudomonas sp. | - |
- |
- |
| 1.4.1.1 | Thermus thermophilus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.1.1 | L-Ala + H2O + NAD+ | - |
Bacillus subtilis | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | - |
Geobacillus stearothermophilus | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | - |
Lysinibacillus sphaericus | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | - |
Pseudomonas sp. | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | - |
Halobacterium salinarum | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | - |
Bacillus cereus | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | - |
Bacillus licheniformis | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | - |
Bacillus japonicum | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | highly specific for L-Ala | Thermus thermophilus | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | highly specific for L-Ala | Mycobacterium tuberculosis | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | highly specific for L-Ala | Kitasatospora aureofaciens | pyruvate + NH3 + NADH | - |
r | |
| 1.4.1.1 | L-Ala + H2O + NAD+ | highly specific for L-Ala | Anabaena cylindrica | pyruvate + NH3 + NADH | - |
r | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.4.1.1 | 8 | - |
reductive amination | Thermus thermophilus |
| 1.4.1.1 | 8 | - |
reductive amination | Anabaena cylindrica |
| 1.4.1.1 | 8.5 | - |
- |
Thermus thermophilus |
| 1.4.1.1 | 8.5 | - |
reductive amination of pyruvate | Bacillus subtilis |
| 1.4.1.1 | 8.5 | - |
reductive amination of pyruvate | Kitasatospora aureofaciens |
| 1.4.1.1 | 8.5 | - |
reductive amination of pyruvate | Bacillus japonicum |
| 1.4.1.1 | 9 | - |
both directions | Pseudomonas sp. |
| 1.4.1.1 | 9 | - |
both directions | Halobacterium salinarum |
| 1.4.1.1 | 9.3 | - |
reductive amination | Mycobacterium tuberculosis |
| 1.4.1.1 | 9.6 | - |
oxidative deamination | Anabaena cylindrica |
| 1.4.1.1 | 9.8 | - |
oxidative deamination | Mycobacterium tuberculosis |
| 1.4.1.1 | 10 | - |
- |
Kitasatospora aureofaciens |
| 1.4.1.1 | 10 | - |
- |
Bacillus japonicum |
| 1.4.1.1 | 10 | 10.5 | oxidative deamination | Bacillus subtilis |
| 1.4.1.1 | 10 | 10.5 | oxidative deamination | Lysinibacillus sphaericus |
| 1.4.1.1 | 10 | 10.5 | oxidative deamination | Kitasatospora aureofaciens |
| 1.4.1.1 | 10 | 10.5 | oxidative deamination | Bacillus japonicum |
| 1.4.1.1 | 10.5 | - |
- |
Lysinibacillus sphaericus |
| 1.4.1.1 | 10.5 | - |
oxidative deamination of L-Ala | Thermus thermophilus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.1.1 | NAD+ | - |
Bacillus subtilis | |
| 1.4.1.1 | NAD+ | - |
Thermus thermophilus | |
| 1.4.1.1 | NAD+ | - |
Geobacillus stearothermophilus | |
| 1.4.1.1 | NAD+ | - |
Lysinibacillus sphaericus | |
| 1.4.1.1 | NAD+ | - |
Pseudomonas sp. | |
| 1.4.1.1 | NAD+ | - |
Halobacterium salinarum | |
| 1.4.1.1 | NAD+ | - |
Bacillus cereus | |
| 1.4.1.1 | NAD+ | - |
Mycobacterium tuberculosis | |
| 1.4.1.1 | NAD+ | - |
Bacillus licheniformis | |
| 1.4.1.1 | NAD+ | - |
Kitasatospora aureofaciens | |
| 1.4.1.1 | NAD+ | - |
Anabaena cylindrica | |
| 1.4.1.1 | NAD+ | - |
Bacillus japonicum | |
| 1.4.1.1 | NADH | - |
Bacillus subtilis | |
| 1.4.1.1 | NADH | - |
Thermus thermophilus | |
| 1.4.1.1 | NADH | - |
Geobacillus stearothermophilus | |
| 1.4.1.1 | NADH | - |
Lysinibacillus sphaericus | |
| 1.4.1.1 | NADH | - |
Pseudomonas sp. | |
| 1.4.1.1 | NADH | - |
Halobacterium salinarum | |
| 1.4.1.1 | NADH | - |
Bacillus cereus | |
| 1.4.1.1 | NADH | - |
Mycobacterium tuberculosis | |
| 1.4.1.1 | NADH | - |
Bacillus licheniformis | |
| 1.4.1.1 | NADH | - |
Kitasatospora aureofaciens | |
| 1.4.1.1 | NADH | - |
Anabaena cylindrica | |
| 1.4.1.1 | NADH | - |
Bacillus japonicum | |
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