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Literature summary extracted from
- Rat liver ferrochelatase. Purification, properties, and stimulation by fatty acids (1981), J. Biol. Chem., 256, 12748-12753.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 4.98.1.1 | in absence of dithiothreitol or glycerol enzyme activity diminishes rapidly | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.98.1.1 | Co2+ | - |
Rattus norvegicus |  |
| 4.98.1.1 | Cu2+ | - |
Rattus norvegicus | |
| 4.98.1.1 | iodoacetamide | - |
Rattus norvegicus | |
| 4.98.1.1 | Mn2+ | - |
Rattus norvegicus | |
| 4.98.1.1 | Pb2+ | - |
Rattus norvegicus | |
| 4.98.1.1 | sulfhydryl reagents | - |
Rattus norvegicus | |
| 4.98.1.1 | Zn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.98.1.1 | 0.0267 | - |
mesoporphyrin IX | - |
Rattus norvegicus | |
| 4.98.1.1 | 0.0285 | - |
protoporphyrin IX | - |
Rattus norvegicus | |
| 4.98.1.1 | 0.0331 | - |
Fe2+ | cosubstrate protoporphyrin | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.98.1.1 | mitochondrion | inner membrane | Rattus norvegicus | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.98.1.1 | Cu2+ | inhibition | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.98.1.1 | 42000 | - |
1 * 42000, SDS-PAGE | Rattus norvegicus |
| 4.98.1.1 | 240000 | - |
gel filtration | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.98.1.1 | Rattus norvegicus | - |
- |
- |
Oxidation Stability
| EC Number | Oxidation Stability | Organism |
|---|---|---|
| 4.98.1.1 | glutathione, cysteine, dithiothreitol protect against autooxidation | Rattus norvegicus |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 4.98.1.1 | side-chain modification | lipoprotein, purified enzyme contains 0.5-1.9 mg fatty acids per mg protein | Rattus norvegicus |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.98.1.1 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.98.1.1 | liver | - |
Rattus norvegicus | - |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 4.98.1.1 | additional information | Rattus norvegicus |
| 4.98.1.1 | stable for at 1 month, -25°C, 50% loss of activity, 4°C, 1 week | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.98.1.1 | mesoporphyrin IX + Fe2+ | - |
Rattus norvegicus | mesoheme + 2 H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | - |
Rattus norvegicus | protoheme + 2 H+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.98.1.1 | ? | 1 * 42000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.98.1.1 | 7.8 | - |
- |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.98.1.1 | 6.8 | 9.5 | - |
Rattus norvegicus |
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