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Literature summary extracted from

  • Matsuura, K.; Hara, A.; Deyashiki, Y.; Iwasa, H.; Kume, T.; Ishikura, S.; Shiraishi, H.; Katagiri, Y.
    Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimeric enzymes (1998), Biochem. J., 336, 429-436.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.20 bezafibric acid DD4 Homo sapiens
1.3.1.20 Clofibric acid DD4, CDD4-1 Homo sapiens
1.3.1.20 fenofibric acid DD4, CDD4-1 Homo sapiens
1.3.1.20 Sulfobromophthalein DD4, CDD4-1 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.20 DD1, DD4, CDD1-4, CDD4-1, all expressed in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.20 C87S DD1 mutant Homo sapiens
1.3.1.20 L54V DD1 mutant, increase in activity towards (S)-indan-1-ol and bile-acids, increased Km for trans-benzene dihydrodiol Homo sapiens
1.3.1.20 additional information CDD1-4 mutant consisting of DD1 with C-terminal end of DD4 shows 10-37fold increase in Km for indan-1-ol and 1,2,3,4-tetrahydronaphth-1-ol and significantly decreased activity towards androstanes, higher activity with bile-acids and 5beta-steroid than DD1 Homo sapiens
1.3.1.20 additional information CDD4-1 mutant consisting of DD4 with C-terminal end of DD1shows new stereospecificity toward indan-1-ol stereomers and increased Km-values with bile acids and 3-hydroxysteroids compared to DD4 Homo sapiens
1.3.1.20 Q172L DD1 mutant Homo sapiens
1.3.1.20 R170H DD1 mutant Homo sapiens
1.3.1.20 R47H DD1 mutant Homo sapiens
1.3.1.20 T38V DD1 mutant Homo sapiens
1.3.1.20 V151M DD1 mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.20 1,10-phenanthroline recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
1.3.1.20 Betamethasone recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
1.3.1.20 Flufenamic acid recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
1.3.1.20 Hexestrol recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
1.3.1.20 indomethacin recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
1.3.1.20 Medroxyprogesterone acetate recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
1.3.1.20 Phenolphthalein recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.20 Homo sapiens
-
 DD1, DD4
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.20 DD1, DD4, CDD1-4, CDD4-1, all recombinant from Escherichia coli Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.20 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.20 (S)-indan-1-ol + NADP+ DD1, DD4, mutant CDD1-4, mutant CDD4-1 Homo sapiens ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.20 NADP+
-
 Homo sapiens