Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hara, A.; Matsuura, K.; Tamada, Y.; Sato, K.; Miyabe, Y.; Deyashiki, Y.; Ishida, N.
    Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells (1996), Biochem. J., 313, 373-376.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.20 DD1, expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.20 1,10-phenanthroline DD1, recombinant DD1, but DD2 less sensitive Homo sapiens
1.3.1.20 1,7-phenanthroline DD1, recombinant DD1, but DD2 less sensitive Homo sapiens
1.3.1.20 chenodeoxycholic acid DD2 very sensitive, DD1 less sensitive, recombinant DD1 Homo sapiens
1.3.1.20 Flufenamic acid DD1, DD2, recombinant DD1 Homo sapiens
1.3.1.20 Hexestrol DD1, DD2, recombinant DD1 Homo sapiens
1.3.1.20 Ibuprofen very sensitive: DD2, less sensitive: DD1, recombinant DD1 Homo sapiens
1.3.1.20 indomethacin DD1, DD2, recombinant DD1 Homo sapiens
1.3.1.20 lithocholic acid DD2, DD1, recombinant DD1 Homo sapiens
1.3.1.20 Ursodeoxycholic acid very sensitiv: DD2, less sensitiv: DD1, recombinant DD1 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.20 Homo sapiens Q04828 DD1, DD2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.20 DD1, recombinant from Escherichia coli Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.20 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.20 11
-
 DD2 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.20 (S)-indan-1-ol + NADP+ recombinant DD1, DD1, DD2 Homo sapiens ?
-
 ?
1.3.1.20 (S)-tetralol + NADP+ DD1, DD2, recombinant DD1 Homo sapiens ?
-
 ?
1.3.1.20 5beta-androstan-3alpha,17beta-diol + NADP+ DD1, DD2, recombinant DD1 Homo sapiens 5beta-androstan-3,17-dione + NADPH
-
 ?
1.3.1.20 5beta-pregnan-3,20-diol + NADP+ DD1, DD2, recombinant DD1 Homo sapiens 5beta-pregnan-20-ol-3-one + NADPH
-
 ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ DD1, DD2, recombinant DD1 Homo sapiens catechol + NAD(P)H
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.1.20 0.0317
-
 trans-benzene dihydrodiol DD2 Homo sapiens
1.3.1.20 0.0533
-
 trans-benzene dihydrodiol DD1 Homo sapiens
1.3.1.20 0.145
-
 trans-benzene dihydrodiol recombinant DD1 Homo sapiens
1.3.1.20 0.158
-
 (S)-indan-1-ol DD2 Homo sapiens
1.3.1.20 0.167
-
 (S)-indan-1-ol DD1 Homo sapiens
1.3.1.20 0.417
-
 (S)-indan-1-ol DD1 recombinant Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.20 NADP+
-
 Homo sapiens
1.3.1.20 NADPH
-
 Homo sapiens