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Literature summary extracted from
- Kinetic studies of the inhibition of a human liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme by bile acids and anti-inflammatory drugs (1995), Biol. Pharm. Bull., 18, 9-12.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.20 | Dehydrolithocholic acid | DD2 | Homo sapiens |  |
| 1.3.1.20 | Flufenamic acid | DD2 | Homo sapiens | |
| 1.3.1.20 | indomethacin | DD2 | Homo sapiens | |
| 1.3.1.20 | lithocholic acid | DD2 | Homo sapiens | |
| 1.3.1.20 | additional information | DD2, product inhibition and inhibition mechanism of bile acids and anti-inflammatory drugs | Homo sapiens | |
| 1.3.1.20 | naproxen | DD2 | Homo sapiens | |
| 1.3.1.20 | ursodeoxylithocholic acid | DD2 | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.20 | additional information | Homo sapiens | involved in the metabolism of steroid hormones and polycyclic aromatic hydrocarbons, and also in the reduction of ketone-containing drugs | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.20 | Homo sapiens | - |
DD2 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.3.1.20 | liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.20 | (S)-indan-1-ol + NADP+ | - |
Homo sapiens | ? | - |
? | |
| 1.3.1.20 | additional information | involved in the metabolism of steroid hormones and polycyclic aromatic hydrocarbons, and also in the reduction of ketone-containing drugs | Homo sapiens | ? | - |
? | |
| 1.3.1.20 | trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Homo sapiens | catechol + NAD(P)H | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.1.20 | DD | - |
Homo sapiens |
| 1.3.1.20 | dihydrodiol dehydrogenase | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.20 | NADP+ | - |
Homo sapiens | |
| 1.3.1.20 | NADPH | - |
Homo sapiens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.3.1.20 | 0.00004 | - |
lithocholic acid | DD2 | Homo sapiens | |
| 1.3.1.20 | 0.00006 | - |
ursodeoxylithocholic acid | DD2 | Homo sapiens | |
| 1.3.1.20 | 0.00009 | - |
Dehydrolithocholic acid | DD2 | Homo sapiens | |
| 1.3.1.20 | 0.0006 | - |
Flufenamic acid | DD2 | Homo sapiens | |
| 1.3.1.20 | 0.0011 | - |
naproxen | DD2 | Homo sapiens | |
| 1.3.1.20 | 0.076 | - |
indomethacin | DD2 | Homo sapiens | |
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