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Literature summary extracted from

  • Matsuura, K.; Hara, A.; Nakayama, T.; Nakagawa, M.; Sawada, H.
    Purification and properties of two multiple forms of dihydrodiol dehydrogenase from guinea-pig testis (1987), Biochim. Biophys. Acta, 912, 270-277.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.20 NaCl DD3 Cavia porcellus
1.3.1.20 potassium phosphate
-
 Cavia porcellus
1.3.1.20 SO42-
-
 Cavia porcellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.20 Barbital DD2, DD4 Cavia porcellus
1.3.1.20 Hexestrol
-
 Cavia porcellus
1.3.1.20 indomethacin
-
 Cavia porcellus
1.3.1.20 NaCl DD2, DD4 Cavia porcellus
1.3.1.20 p-chloromercuriphenyl sulfonate inhibits only DD3 Cavia porcellus
1.3.1.20 quercitrin
-
 Cavia porcellus
1.3.1.20 sorbinil DD2, DD3 is more sensitive, DD4 no inhibition Cavia porcellus
1.3.1.20 Stilbestrol
-
 Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.20 30000
-
 about, DD2-DD4. gel filtration Cavia porcellus
1.3.1.20 32000
-
 1 * 32000, DD3, and 1 * 36000, DD4, SDS-PAGE Cavia porcellus
1.3.1.20 36000
-
 1 * 32000, DD3, and 1 * 36000, DD4, SDS-PAGE Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ Cavia porcellus
-
 catechol + NAD(P)H
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.20 Cavia porcellus
-
 3 forms: DD2 pI form 5.4, DD3 pI 5.0 form, and DD4 pI 4.2 form
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.20
-
 Cavia porcellus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ probably identical with D-xylose dehydrogenase EC 1.1.1.179 Cavia porcellus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.20 testis
-
 Cavia porcellus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.20 additional information
-
-
 Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.20 4-carboxybenzaldehyde + NADPH
-
 Cavia porcellus ?
-
 ?
1.3.1.20 4-nitrobenzaldehyde + NAD(P)H DD2, DD3 Cavia porcellus 4-nitrobenzylalcohol + NAD(P)+
-
 ?
1.3.1.20 alicyclic alcohol + NAD(P)+ not: Cavia porcellus ?
-
 ?
1.3.1.20 D-galactose + NADP+ only isoform DD3 Cavia porcellus D-galactono-1,5-lactone + NADPH
-
 ?
1.3.1.20 D-glucose + NADP+ only isoform DD3 Cavia porcellus D-glucono-1,5-lactone + NADPH + H+
-
 ?
1.3.1.20 D-glucuronate + NADP+ isoform DD4 no activity Cavia porcellus D-glucurono-1,5-lactone + NADPH
-
 r
1.3.1.20 D-glyceraldehyde + NADPH DD2 and DD3 show high activity, DD4 only shows low activity Cavia porcellus ?
-
 ?
1.3.1.20 D-xylose + NADP+
-
 Cavia porcellus D-xylono-1,5-lactone + NADPH + H+
-
 ?
1.3.1.20 diacetyl + NADPH
-
 Cavia porcellus ?
-
 ?
1.3.1.20 L-glyceraldehyde + NADPH DD2 and DD3 show high activity, DD4 only shows low activity Cavia porcellus ?
-
 ?
1.3.1.20 additional information not: hydroxy steroids Cavia porcellus additional information
-
 ?
1.3.1.20 additional information xenobiotic acyclic alcohols (Japanese monkey) Cavia porcellus additional information
-
 ?
1.3.1.20 additional information 3 forms: DD4 pI 4.2, DD3 pI 5.0 and DD2 pI 5.4, isoform DD4: strict specificity for benzene dihydrodiol and NADP+, and for reduced pyridine aldehydes, glyceraldehyde and, at low rate, for diacetyl, isoform DD3: oxidizes n-butanol, glycerol and sorbitol as well as benzene dihydrodiol in the presence of NADP+ or NAD+, and exhibits much higher reductase activity towards various aldehydes, aldoses and diacetyl Cavia porcellus additional information
-
 ?
1.3.1.20 pyridine-3-aldehyde + NADPH
-
 Cavia porcellus ?
-
 ?
1.3.1.20 pyridine-4-aldehyde + NADPH
-
 Cavia porcellus ?
-
 ?
1.3.1.20 succinic semialdehyde + NADPH isoform DD4 low activity Cavia porcellus ?
-
 ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
 Cavia porcellus catechol + NAD(P)H
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.1.20 monomer 1 * 32000, DD3, and 1 * 36000, DD4, SDS-PAGE Cavia porcellus

Synonyms

EC Number Synonyms Comment Organism
1.3.1.20 DD
-
 Cavia porcellus
1.3.1.20 dihydrodiol dehydrogenase
-
 Cavia porcellus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.20 NADP+ dependent on, DD2 and DD4 nearly no activity with NAD+ Cavia porcellus
1.3.1.20 NADPH
-
 Cavia porcellus