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Literature summary extracted from

  • Naguib, F.N.M.; El Kouni, M.H.; Cha, S.
    Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver (1989), Biochem. Pharmacol., 38, 1471-1480.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.2 1-deazauracil i.e. 2,6-pyridinediol Mus musculus
1.3.1.2 3-deazauracil i.e. 2,4-pyridinediol Mus musculus
1.3.1.2 5,6-dioxyuracil i.e. alloxan Mus musculus
1.3.1.2 5-benzyloxybenzyluracil
-
 Mus musculus
1.3.1.2 5-benzyluracil
-
 Mus musculus
1.3.1.2 5-nitrobarbituric acid
-
 Mus musculus
1.3.1.2 additional information
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.2 cytoplasm
-
 Mus musculus 5737
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Mus musculus
-
 extensive overview of literature data concerning inhibitors and substrates
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.2 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 5,6-dihydrouracil + NADP+
-
 Mus musculus uracil + NADPH
-
 r
1.3.1.2 dihydrothymine + NADP+
-
 Mus musculus thymine + NADPH
-
 r
1.3.1.2 additional information
-
 Mus musculus ?
-
 ?
1.3.1.2 thymine + NADPH
-
 Mus musculus dihydrothymine + NADP+
-
 r
1.3.1.2 uracil + NADPH
-
 Mus musculus 5,6-dihydrouracil + NADP+
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.2 37
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 NADPH
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.2 additional information
-
 additional information
-
 Mus musculus
1.3.1.2 0.0002
-
 5-benzyloxybenzyluracil
-
 Mus musculus
1.3.1.2 0.0005
-
 1-deazauracil
-
 Mus musculus
1.3.1.2 0.0021
-
 3-deazauracil
-
 Mus musculus
1.3.1.2 0.0034
-
 5-benzyluracil
-
 Mus musculus
1.3.1.2 0.0038
-
 5-nitrobarbituric acid
-
 Mus musculus
1.3.1.2 0.0066
-
 5,6-dioxyuracil
-
 Mus musculus