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Literature summary extracted from

  • Goudgaon, N.M.; Naguib, F.N.M.; el Kouni, M.H.; Schinazi, R.F.
    Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase (1993), J. Med. Chem., 36, 4250-4254.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.2 5-(phenylselenenyl)uracil
-
 Mus musculus
1.3.1.2 5-(phenylthio)uracil
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.2 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 uracil + NADPH
-
 Mus musculus 5,6-dihydrouracil + NADP+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.2 37
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 NADPH
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.2 0.0048
-
 5-(phenylselenenyl)uracil
-
 Mus musculus
1.3.1.2 0.0054
-
 5-(phenylthio)uracil
-
 Mus musculus