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Literature summary extracted from

  • Balzarini, J.; Sienaert, R.; Liekens, S.; Van Kuilenburg, A.; Carangio, A.; Esnouf, R.; De Clercq, E.; McGuigan, C.
    Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase (2002), Mol. Pharmacol., 61, 1140-1145.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.2 (E)-5-[2-bromovinyl-]uracil 50% inhibition at 0.01 mM, no inhibition by free base Homo sapiens
1.3.1.2 (E)-5-[2-bromovinyl-]uracil 50% inhibition at 0.01 mM, no inhibition by free base Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.2 thymine + NADPH Mus musculus
-
 dihydrothymine + NADP+
-
 r
1.3.1.2 thymine + NADPH Homo sapiens
-
 dihydrothymine + NADP+
-
 r
1.3.1.2 uracil + NADPH Mus musculus
-
 5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 uracil + NADPH Homo sapiens
-
 5,6-dihydrouracil + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Homo sapiens
-
-
-
1.3.1.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.2 blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 5-fluorouracil + NADPH + H+
-
 Mus musculus 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 5-fluorouracil + NADPH + H+
-
 Homo sapiens 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 thymine + NADPH
-
 Mus musculus dihydrothymine + NADP+
-
 ?
1.3.1.2 thymine + NADPH
-
 Mus musculus dihydrothymine + NADP+
-
 r
1.3.1.2 thymine + NADPH
-
 Homo sapiens dihydrothymine + NADP+
-
 ?
1.3.1.2 thymine + NADPH
-
 Homo sapiens dihydrothymine + NADP+
-
 r
1.3.1.2 uracil + NADPH
-
 Mus musculus 5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 uracil + NADPH
-
 Homo sapiens 5,6-dihydrouracil + NADP+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 NADPH
-
 Mus musculus
1.3.1.2 NADPH
-
 Homo sapiens