EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.2 | 0.004 | - |
Uracil | - |
Rattus norvegicus | |
1.3.1.2 | 0.017 | - |
NADPH | - |
Rattus norvegicus | |
1.3.1.2 | 0.6 | - |
Dihydrothymine | in presence of dihydrouracil | Rattus norvegicus | |
1.3.1.2 | 2 | - |
5,6-dihydrouracil | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.3.1.2 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.2 | 5,6-dihydrouracil + NADP+ | Rattus norvegicus | - |
uracil + NADPH | - |
r | |
1.3.1.2 | uracil + NADPH | Rattus norvegicus | rate limiting step in catabolic breakdown of uracil to beta-alanine | 5,6-dihydrouracil + NADP+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.2 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.3.1.2 | partial | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.1.2 | liver | - |
Rattus norvegicus | - |
EC Number | Storage Stability | Organism |
---|---|---|
1.3.1.2 | -15°C, 20% loss of activity after 1 month | Rattus norvegicus |
1.3.1.2 | -20°C, 2 mg/ml protein, 10% loss of activity after 2 weeks | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.2 | 5,6-dihydrouracil + NADP+ | - |
Rattus norvegicus | uracil + NADPH | - |
r | |
1.3.1.2 | uracil + NADPH | - |
Rattus norvegicus | 5,6-dihydrouracil + NADP+ | - |
r | |
1.3.1.2 | uracil + NADPH | rate limiting step in catabolic breakdown of uracil to beta-alanine | Rattus norvegicus | 5,6-dihydrouracil + NADP+ | - |
r |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.3.1.2 | 7 | 7.6 | uracil reduction | Rattus norvegicus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.3.1.2 | 6.7 | 7.9 | about 80% of activity maximum at pH 6.7 and 7.9, uracil reduction | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.2 | NADP+ | - |
Rattus norvegicus | |
1.3.1.2 | NADPH | - |
Rattus norvegicus |