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Literature summary extracted from

  • Fritzson, P.
    Properties and assay of dihydrouracil dehydrogenase of rat liver (1960), J. Biol. Chem., 235, 719-725.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.2 0.004
-
Uracil
-
Rattus norvegicus
1.3.1.2 0.017
-
NADPH
-
Rattus norvegicus
1.3.1.2 0.6
-
Dihydrothymine in presence of dihydrouracil Rattus norvegicus
1.3.1.2 2
-
5,6-dihydrouracil
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.2 cytoplasm
-
Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.2 5,6-dihydrouracil + NADP+ Rattus norvegicus
-
uracil + NADPH
-
r
1.3.1.2 uracil + NADPH Rattus norvegicus rate limiting step in catabolic breakdown of uracil to beta-alanine 5,6-dihydrouracil + NADP+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.2 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.2 liver
-
Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
1.3.1.2 -15°C, 20% loss of activity after 1 month Rattus norvegicus
1.3.1.2 -20°C, 2 mg/ml protein, 10% loss of activity after 2 weeks Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 5,6-dihydrouracil + NADP+
-
Rattus norvegicus uracil + NADPH
-
r
1.3.1.2 uracil + NADPH
-
Rattus norvegicus 5,6-dihydrouracil + NADP+
-
r
1.3.1.2 uracil + NADPH rate limiting step in catabolic breakdown of uracil to beta-alanine Rattus norvegicus 5,6-dihydrouracil + NADP+
-
r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.2 7 7.6 uracil reduction Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.3.1.2 6.7 7.9 about 80% of activity maximum at pH 6.7 and 7.9, uracil reduction Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 NADP+
-
Rattus norvegicus
1.3.1.2 NADPH
-
Rattus norvegicus