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Literature summary extracted from

  • Milano, G.; Fischel, J.L.; Etienne, M.C.; Renee, N.; Formento, P.; Thyss, A.; Gaspard, M.H.; Thill, L.; Cupissol, D.
    Inhibition of dihydropyrimidine dehydrogenase by alpha-interferon: Experimental data on human tumor cell lines (1994), Cancer Chemother. Pharmacol., 34, 147-152.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.1.1 medicine target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate Homo sapiens
1.3.1.2 medicine target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.1 interferon-alpha-2a cell lines CAL 27, CAL 33, CAL 51, CAL 7, PANC 3 Homo sapiens
1.3.1.2 alpha-2a-interferon cell lines CAL 27, CAL 33, CAL 51, CAL 7, PANC 3 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.1 5-fluorouracil + NADPH + H+ Homo sapiens
-
 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 5-fluorouracil + NADPH + H+ Homo sapiens
-
 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.1 Homo sapiens
-
-
-
1.3.1.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.1 carcinoma cell cell line CAL 7 Homo sapiens
-
1.3.1.2 CAL-27 cell
-
 Homo sapiens
-
1.3.1.2 CAL-33 cell
-
 Homo sapiens
-
1.3.1.2 CAL-51 cell
-
 Homo sapiens
-
1.3.1.2 carcinoma cell cancer cell line CAL 7 Homo sapiens
-
1.3.1.2 PANC-3 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.1 0.118
-
 cell line CAL 27 Homo sapiens
1.3.1.1 0.122
-
 cell line CAL 7 Homo sapiens
1.3.1.1 0.184
-
 cell line CAL 33 Homo sapiens
1.3.1.1 0.265
-
 cell line PANC 3 Homo sapiens
1.3.1.1 0.318
-
 cell line CAL 51 Homo sapiens
1.3.1.2 0.118
-
 cell line CAL 27 Homo sapiens
1.3.1.2 0.122
-
 cell line CAL 7 Homo sapiens
1.3.1.2 0.184
-
 cell line CAL 33 Homo sapiens
1.3.1.2 0.265
-
 cell line PANC 3 Homo sapiens
1.3.1.2 0.318
-
 cell line CAL 51 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.1 5-fluorouracil + NADPH + H+
-
 Homo sapiens 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 5-fluorouracil + NADPH + H+
-
 Homo sapiens 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.1 DPD
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.1 37
-
 assay at Homo sapiens
1.3.1.2 37
-
 assay at Homo sapiens